Therapeutic potential and limitations of curcumin as antimetastatic agent

被引：20

作者：

Dytrych, Petr ^{[1
,2
]}

Kejik, Zdenek ^{[3
,4
,5
]}

Hajduch, Jan ^{[3
]}

Kaplanek, Robert ^{[3
]}

Vesela, Katerina ^{[3
,4
,5
]}

Kucnirova, Katerina ^{[3
,4
,5
]}

Skalickova, Marketa ^{[3
,4
,5
]}

Venhauerova, Anna ^{[3
,4
,5
]}

Hoskovec, David ^{[1
,2
]}

Martasek, Pavel ^{[4
,5
]}

Jakubek, Milan ^{[3
,4
,5
]}

机构：

[1] Charles Univ Prague, Fac Med 1, Dept Surg 1, Dept Abdominal Thorac Surg & Traumatol, U Nemocnice 2, Prague 12108, Czech Republic

[2] Gen Univ Hosp, U Nemocnice 2, Prague 12108, Czech Republic

[3] Charles Univ Prague, Fac Med 1, BIOCEV, Prumyslova 595, Vestec 25250, Czech Republic

[4] Charles Univ Prague, Fac Med 1, Dept Paediat & Inherited Metab Disorders, Ke Karlovu 455-2, Prague 12808, Czech Republic

[5] Gen Univ Hosp Prague, Ke Karlovu 455-2, Prague 12808, Czech Republic

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 163卷

关键词：

Curcumin; Metastasis; Migrastatic agents; Tumour targeting; Nanoparticles; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN BREAST-CANCER; SQUAMOUS-CELL CARCINOMA; LEWIS LUNG-CARCINOMA; IN-VITRO; TUMOR-GROWTH; HELICOBACTER-PYLORI; PANCREATIC-CANCER; DRUG-DELIVERY;

D O I：

10.1016/j.biopha.2023.114758

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Treatment of metastatic cancer is one of the biggest challenges in anticancer therapy. Curcumin is interesting nature polyphenolic compound with unique biological and medicinal effects, including repression of metastases. High impact studies imply that curcumin can modulate the immune system, independently target various met-astatic signalling pathways, and repress migration and invasiveness of cancer cells. This review discusses the potential of curcumin as an antimetastatic agent and describes potential mechanisms of its antimetastatic ac-tivity. In addition, possible strategies (curcumin formulation, optimization of the method of administration and modification of its structure motif) to overcome its limitation such as low solubility and bioactivity are also presented. These strategies are discussed in the context of clinical trials and relevant biological studies.

引用

页数：37

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