Immune response in blood before and after epileptic and psychogenic non-epileptic seizures

被引：8

作者：

Ahl, Matilda ^{[1
,2
,3
]}

Taylor, Marie K. ^{[1
,2
,3
]}

Avdic, Una ^{[1
,2
,3
]}

Lundin, Anna ^{[1
,2
]}

Andersson, My ^{[1
,2
,3
]}

Amandusson, Asa ^{[4
]}

Kumlien, Eva ^{[5
]}

Strandberg, Maria Compagno ^{[6
]}

Ekdahl, Christine T. ^{[1
,2
,3
]}

机构：

[1] Lund Univ, Div Clin Neurophysiol, Lund, Sweden

[2] Lund Univ, Dept Clin Sci, Lund, Sweden

[3] Lund Univ, Lund Epilepsy Ctr, Dept Clin Sci, Lund, Sweden

[4] Uppsala Univ, Dept Med Sci, Clin Neurophysiol, Uppsala, Sweden

[5] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[6] Lund Univ, Dept Clin Sci, Div Neurol, Lund, Sweden

来源：

HELIYON | 2023年 / 9卷 / 03期

基金：

瑞典研究理事会;

关键词：

Epilepsy; Psychogenic non -epileptic seizure; EEG; Immune response; Biomarker; Interleukin-6; INTERLEUKIN-1 RECEPTOR ANTAGONIST; CEREBROSPINAL-FLUID; CYTOKINES; IL-6; MECHANISMS; EXPRESSION; DIAGNOSIS; IMPACT;

D O I：

10.1016/j.heliyon.2023.e13938

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non -epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified tem-poral or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no in-crease in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling in-dependent of co-morbidities.

引用

页数：10

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