Tissue-resident memory T (TRM) cells: Front-line workers of the immune system

Tissue-resident memory T (T-RM) cells play a vital role in local immune protection against infection and cancer. The location of T-RM cells within peripheral tissues at sites of pathogen invasion allows for the rapid detection and elimination of microbes, making their generation an attractive goal for the development of next-generation vaccines. Here, we discuss differential requirements for CD8(+) T-RM cell development across tissues with implications for establishing local prophylactic immunity, emphasizing the role of tissue-derived factors, local antigen, and adjuvants on T-RM cell generation in the context of vaccination.