Say ?NO? to plant stresses: Unravelling the role of nitric oxide under abiotic and biotic stress

Nitric oxide (NO) is a diatomic gaseous molecule, which plays different roles in different strata of organisms. Discovered as a neurotransmitter in animals, NO has now gained a significant place in plant signaling cascade. NO regulates plant growth and several developmental processes including germination, root formation, stomatal movement, maturation and defense in plants. Due to its gaseous state, it is unchallenging for NO to reach different parts of cell and counterpoise antioxidant pool. Various abiotic and biotic stresses act on plants and affect their growth and development. NO plays a pivotal role in alleviating toxic effects caused by various stressors by modulating oxidative stress, antioxidant defense mechanism, metal transport and ion homeostasis. It also modulates the activity of some transcriptional factors during stress conditions in plants. Besides its role during stress conditions, interaction of NO with other signaling molecules such as other gasotransmitters (hydrogen sulfide), phytohormones (abscisic acid, salicylic acid, jasmonic acid, gibberellin, ethylene, brassi-nosteroids, cytokinins and auxin), ions, polyamines, etc. has been demonstrated. These interactions play vital role in alleviating plant stress by modulating defense mechanisms in plants. Taking all these aspects into consideration, the current review focuses on the role of NO and its interaction with other signaling molecules in regulating plant growth and development, particularly under stressed conditions.