177Lu-DOTATATE (Lutathera) Therapy in 68Ga-DOTATATE PET/CT-Negative Liver Metastases of a Neuroendocrine Tumor

被引：2
|
作者：
Ventura, David [1 ]
Roll, Wolfgang [1 ]
Kasper, Hans-Udo [2 ]
Rahbar, Kambiz [1 ]
Stegger, Lars [1 ]
机构：
[1] Univ Hosp Muenster, Dept Nucl Med, Albert Schweitzer Campus 1,Gebaude A1, D-48149 Munster, Germany
[2] Clemenshosp Muenster, Inst Pathol, Munster, Germany
来源：
CLINICAL NUCLEAR MEDICINE | 2023年 / 48卷 / 12期
关键词：
PRRT; GEP-NET; PET/CT; DOTATATE; SSTR; ANALOG;
D O I：
10.1097/RLU.0000000000004888
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A 73-year-old man with metastatic pancreatic neuroendocrine tumor was evaluated with Ga-68-DOTATATE PET/CT for peptide receptor radionuclide therapy. Both PET-positive and negative lesions were seen in the liver, along with extrahepatic metastases. Histopathology was obtained from one of the PET-negative liver lesions to exclude secondary malignancy. Histology confirmed a well-differentiated (G2) metastasis of pNET with high somatostatin receptor expression. We initiated peptide receptor radionuclide therapy with close monitoring of the PET-negative liver metastases. We present a rare case, where posttherapeutic scintigraphy revealed vigorous uptake of Lu-177-DOTATATE even in the Ga-68-DOTATATE PET-negative liver metastases. Follow-up PET/CT showed a partial response to therapy.
引用
收藏
页码：E585 / E587
页数：3
相关论文
共 50 条
  • [1] Differential Detection of Hepatic Metastases on 68Ga-DOTATATE PET/CT and 177Lu-DOTATATE SPECT/CT
    Zahed, Hanan
    Beauregard, Jean-Mathieu
    Abikhzer, Gad
    Rush, Christopher
    Probst, Stephan
    CLINICAL NUCLEAR MEDICINE, 2023, 48 (01) : E12 - E15
  • [2] Comparison of 68Ga-DOTATATE and 177Lu-DOTATATE kinetics in neuroendocrine tumors
    Ilan, E.
    Lubberink, M.
    Sandstrom, M.
    Jahn, U.
    Velikyan, I.
    Andersson, C.
    Fross-Baron, K.
    Sundin, A.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2018, 45 : S276 - S277
  • [3] Prediction of 177Lu-DOTATATE Therapy Outcomes in Neuroendocrine Tumor Patients Using Semi-Automatic Tumor Delineation on 68Ga-DOTATATE PET/CT
    Lee, Hwan
    Kipnis, Sarit T.
    Niman, Remy
    O'Brien, Sophia R.
    Eads, Jennifer R.
    Katona, Bryson W.
    Pryma, Daniel A.
    CANCERS, 2024, 16 (01)
  • [4] Quantitative 68Ga-DOTATATE PET/CT Parameters for the Prediction of Therapy Response in Patients with Progressive Metastatic Neuroendocrine Tumors Treated with 177Lu-DOTATATE
    Ortega, Claudia
    Wong, Rebecca K. S.
    Schaefferkoetter, Josh
    Veit-Haibach, Patrick
    Myrehaug, Sten
    Juergens, Rosalyn
    Laidley, David
    Anconina, Reut
    Liu, Amy
    Metser, Ur
    JOURNAL OF NUCLEAR MEDICINE, 2021, 62 (10) : 1406 - 1414
  • [5] Malignant insulinoma: 18F-DOPA and 68Ga-DOTATATE PET/CT and treatment with 177Lu-DOTATATE
    Erhamamci, S.
    Sager, S.
    Asa, S.
    Uslu, L.
    Akgun, E.
    Sonmezoglu, K.
    REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR, 2020, 39 (06): : 383 - 386
  • [6] Neuroendocrine Tumor Therapy: 177Lu-DOTATATE
    Mittra, Erik S.
    AMERICAN JOURNAL OF ROENTGENOLOGY, 2018, 211 (02) : 278 - 285
  • [7] Brain Metastases of a Neuroendocrine Tumor Visualized by 68Ga-DOTATATE PET/CT
    Hoberueck, Sebastian
    Michler, Enrico
    Zoephel, Klaus
    Platzek, Ivan
    Kotzerke, Joerg
    Brogsitter, Claudia
    CLINICAL NUCLEAR MEDICINE, 2019, 44 (01) : 50 - 52
  • [8] Differences in tumor-to-normal organ SUV ratios measured with 68Ga-DOTATATE PET compared with 177Lu-DOTATATE SPECT in patients with neuroendocrine tumors
    Wong, Ka Kit
    Frey, Kirk A.
    Niedbala, Jeremy
    Kaza, Ravi K.
    Worden, Francis P.
    Fitzpatrick, Kellen J.
    Dewaraja, Yuni K.
    NUCLEAR MEDICINE COMMUNICATIONS, 2022, 43 (08) : 892 - 900
  • [9] 68Ga-DOTATATE PET/CT in Primary Hepatic Neuroendocrine Tumor
    Gorla, Arun Kumar Reddy
    Basher, Rajender Kumar
    Kaman, Lileshwar
    Bal, Amanjit
    Bhattacharya, Anish
    Mittal, Bhagwant Rai
    CLINICAL NUCLEAR MEDICINE, 2017, 42 (02) : 118 - 120
  • [10] 177Lu-DOTATATE Theranostics Predicting Renal Dosimetry From Pretherapy 68Ga-DOTATATE PET and Clinical Biomarkers
    Peterson, Avery B.
    Wang, Chang
    Wong, Ka Kit
    Frey, Kirk A.
    Muzik, Otto
    Schipper, Matthew J.
    Dewaraja, Yuni K.
    CLINICAL NUCLEAR MEDICINE, 2023, 48 (05) : 393 - 399
12345