On a Novel Approach to Investigation and Evaluation of the Efficacy of DNA-Binding Radioprotectors

被引：1

作者：

Kolyvanova, M. A. ^{[1
,2
]}

Lifanovsky, N. S. ^{[1
]}

Nikitin, E. A. ^{[3
]}

Klimovich, M. A. ^{[1
,2
]}

Belousov, A. V. ^{[2
]}

Tyurin, V. Y. ^{[3
]}

Kuzmin, V. A. ^{[1
]}

Morozov, V. N. ^{[1
]}

机构：

[1] Russian Acad Sci, Emanuel Inst Biochem Phys, Moscow 119334, Russia

[2] Fed Med Biol Agcy Russian Federat, Burnazyan Fed Med Biophys Ctr, Moscow 123098, Russia

[3] Lomonosov Moscow State Univ, Fac Chem, Moscow 119991, Russia

来源：

HIGH ENERGY CHEMISTRY | 2024年 / 58卷 / 01期

关键词：

liquid-crystalline DNA; circular dichroism; radioprotectors; Hoechst; 33258; ionizing radiation; RADIATION COUNTERMEASURES; CIRCULAR-DICHROISM; HOECHST; 33258; PROTEIN; DAMAGE; BISBENZIMIDAZOLE; MECHANISM; LIGANDS;

D O I：

10.1134/S0018143924010107

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A fundamental possibility of using the ability of low-molecular-weight DNA molecules to form optically active cholesteric liquid-crystalline dispersions (CLCDs) to estimate the efficacy of DNA-binding radioprotectors is studied. On the example of the well-known dye Hoechst 33 258, which interacts with DNA by the minor-groove-binding and has pronounced radioprotective properties, it is shown that the change in the amplitude of anomalous signal of circular dichroism of the CLCDs formed from DNA molecules preliminarily irradiated with X-rays in the absence and in the presence of the test compound makes it possible to estimate the value of its protective effect.

引用

页码：134 / 142

页数：9

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