SARS-CoV-2 vaccines from A to Z: A review of the current challenges

被引：0

作者：

Albalaty, J. M. ^{[1
]}

Forsan, F. H. ^{[2
]}

Awad, S. S. ^{[3
]}

Elsadek, E. N. ^{[4
]}

Rahman, A. A. G. ^{[5
]}

Badawy, M. E. S. M. ^{[6
]}

Khalfallah, M. K. E. ^{[7
]}

El-Wakil, E. S. ^{[8
]}

Ahmed, I. L. ^{[9
]}

Ali, I. Z. ^{[9
]}

Nofal, S. A. ^{[10
]}

Elsapagh, M. R. ^{[11
]}

Gomaa, M. A. ^{[12
]}

Bougafa, E. H. F. ^{[13
]}

Mahmoud, Somaya Abdulbaset ^{[14
]}

Moustafa, A. M. ^{[15
]}

Ali, M. F. ^{[16
]}

Barakat, M. H. ^{[17
]}

Kandeel, M. A. ^{[18
]}

Sebaei, E. A. A. ^{[19
]}

Mahmoud, Ghada Abd-Elmonsef ^{[20
]}

机构：

[1] Assiut Univ, Fac Sci, Dept Chem, Assiut, Egypt

[2] Anim Prod Res Inst APRI, Agr Res Ctr ARC, Giza, Egypt

[3] Cairo Univ, Fac Sci, Chem Biochem Dept, Giza, Egypt

[4] Tokushima Univ, Inst Biomed Sci, Dept Pharmacokinet & Biopharmaceut, 1 78 1 Sho machi, Tokushima 7708505, Japan

[5] South Valley Univ, Fac Oral & Dent Med, Dept Oral & Maxillofacial Pathol, Qena 83523, Egypt

[6] Al Azhar Univ, Fac Pharm Girls, Dept Microbiol & Immunol, Cairo, Egypt

[7] Anim Hlth Res Inst AHRI, Giza, Egypt

[8] Theodor Bilharz Res Inst, Dept Parasitol, Imbaba PO 30, Giza 12411, Egypt

[9] Cairo Univ, Fac Vet Med, Dept food Hyg & control, Giza, Egypt

[10] Zagazig Univ, Fac Agr Sci, Genet Dept, Zagazig, Egypt

[11] Cairo Univ, Fac Pharm, Giza, Egypt

[12] Ain Shams Univ, Fac Sci, Bot & Chem Dept, Cairo, Egypt

[13] Tobruk Univ, Fac Sci, Microbiol Dept, Tobruk, Libya

[14] October 6th Univ, Fac Pharm, Giza, Egypt

[15] Cairo Univ, Fac Sci, Zool Dept, Giza, Egypt

[16] Ain shams Univ, Fac Sci, Biochem Dept, Cairo, Egypt

[17] Al Azhar Univ, Fac Sci, Microbiol & Chem Dept, Cairo, Egypt

[18] Menoufia Univ, Fac Educ, Dept Chem, Menoufia, Egypt

[19] Cairo Univ, Fac Sci, Chem & Zool Dept, Giza, Egypt

[20] Assiut Univ, Fac Sci, Bot & Microbiol Dept, Assiut 71516, Egypt

来源：

GLOBAL NEST JOURNAL | 2023年 / 25卷 / 04期

关键词：

SARS-CoV-2; vaccines; COVID-19; neutralizing antibodies; Lambada mutation; delta mutation; mutant omicron; COVID-19; VACCINE; INFLUENZA VACCINE; DOUBLE-BLIND; IMMUNOGENICITY; SAFETY; TRANSPLANT; INJECTION; INFECTION; SCB-2019; EFFICACY;

D O I：

10.30955/gnj.004651

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

COVID-19 pandemic is a major worldwide health disaster firstly reported in December 2019. The Food and Drug Administration (FDA) has offered the public hope of halting it, authorizing vaccinations for emergency use with more than 85% efficacy against serious acute respiratory syndrome (SARS-CoV-2). Recent outbreaks of SARS-CoV-2 variations including spike-protein mutations, the key vaccines viral target for immune response, have prompted a thorough investigation into the vaccine's long-term effectiveness. Consequently, this review assayed the details on SARS-CoV-2 infection mechanism and how to control the infection by different types of SARS-CoV-2 vaccines, and their effectiveness against other mutant strains. Additionally, the review summarized the different complaints which have been recorded after vaccination. In conclusion, these negative effects must be constantly weighed against the predicted advantages in terms of disease prevention. Although COVID-19 vaccination is recommended for everyone aged 5 years and older, SARS-CoV-2 is high likely to continue to be a pandemic infectious as a result of the broadcasting of variants of the virus.

引用

页码：148 / 171

页数：24

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