Modified Estrogen-Progesterone Induction Method of Mammary Gland Hyperplasia in Rats

被引：0
|
作者：
Semenov, A. L. [1 ]
Tyndyk, M. L. [1 ]
Von, Yu. D. [1 ]
Radetskaya, E. A. [1 ]
Kruglov, A. S. [1 ]
Dorofeeva, A. A. [1 ]
Mizgirev, I. V. [1 ]
Ermakova, E. D. [1 ]
Panchenko, A. V. [1 ]
机构：
[1] Minist Hlth Russian Federat, NN Petrov Natl Med Res Ctr Oncol, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 175卷 / 1期
基金：
俄罗斯科学基金会;
关键词：
model; mammary gland hyperplasia; hormones; breast; hyperplasia;
D O I：
10.1007/s10517-023-05821-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In female Wistar rats, mammary gland hyperplasia (MGH) was modeled according to a modified protocol involving estrogen-progesterone induction and taking into account the duration of the estrous cycle of this animal species. MGH was induced over four 7-day cycles; each cycle included subcutaneous administration of 17 & beta;-estradiol (0.5 mg/kg) for 4 days, injection of progesterone (5 mg/kg) on day 5, then 2 days without injections. In females with MGH, a significant increase in the height and diameter of the nipples of the mammary glands was recorded, two types of changes were observed in the gland tissue: tubuloalveolar and lobuloalveolar hyperplasia. The study confirmed the development of MGH in rats by a modified method.
引用
收藏
页码：112 / 115
页数：4
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