A Straightforward Synthesis of Emericellamide A Using Matteson's Homologation Approach

The Matteson homologation is the perfect approach for the synthesis of polyketide-peptide natural products such as the emericellamides. In only four steps, the polyketide fragment with three stereo genic centers can be obtained as a single stereoisomer. The peptide fragment is easily available via solid-phase peptide synthesis.