Cortical Sensorimotor Integration as a Neural Origin of Impaired Grip Force Direction Control following Stroke

被引:0
|
作者
Schranz, Christian [1 ,2 ]
Seo, Na Jin [1 ,2 ,3 ]
机构
[1] Med Univ South Carolina, Coll Hlth Profess, Dept Hlth Sci & Res, Charleston, SC 29425 USA
[2] Ralph H Johnson VA Hlth Care Syst, Charleston, SC 20401 USA
[3] Med Univ South Carolina, Coll Hlth Profess, Dept Rehabil Sci, Charleston, SC 29425 USA
基金
美国国家卫生研究院;
关键词
stroke; upper extremity; rehabilitation; sensory afferent inhibition; sensorimotor integration; feedback motor control; TMS; paired associative stimulation; TRANSCRANIAL MAGNETIC STIMULATION; LATENCY AFFERENT INHIBITION; FUGL-MEYER ASSESSMENT; MOTOR CORTEX; POWER GRIP; SOMATOSENSORY INPUT; OBJECT MANIPULATION; BLOCK TEST; EXCITABILITY; PATIENT;
D O I
10.3390/brainsci14030253
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Stroke is a major cause of disability worldwide. Upper limb impairment is prevalent after stroke. One of the post-stroke manifestations is impaired grip force directional control contributing to diminished abilities to grip and manipulate objects necessary for activities of daily living. The objective of this study was to investigate the neural origin of the impaired grip force direction control following stroke. Due to the importance of online adjustment of motor output based on sensory feedback, it was hypothesized that grip force direction control would be associated with cortical sensorimotor integration in stroke survivors. Methods: Ten chronic stroke survivors participated in this study. Cortical sensorimotor integration was quantified by short latency afferent inhibition (SAI), which represents the responsiveness of the primary motor cortex to somatosensory input. Grip force direction control was assessed during paretic grip. Results: Grip force direction control was significantly associated with SAI. This relationship was independent of sensory impairment level. Conclusions: Cortical sensorimotor integration may play a significant role in the grip force direction control important for gripping and manipulating objects with the affected hand following stroke. This knowledge may be used to inform personalized rehabilitation treatment. For example, for patients with impaired grip force direction control, behavioral therapy focusing on feedback motor control, augmented by use of brain stimulation to reinforce cortical sensorimotor integration such as paired associative stimulation, may be applied.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Altered phalanx force direction during power grip following stroke
    Enders, Leah R.
    Seo, Na Jin
    EXPERIMENTAL BRAIN RESEARCH, 2015, 233 (06) : 1677 - 1688
  • [2] Altered digit force direction during pinch grip following stroke
    Seo, Na Jin
    Rymer, William Z.
    Kamper, Derek G.
    EXPERIMENTAL BRAIN RESEARCH, 2010, 202 (04) : 891 - 901
  • [3] Altered digit force direction during pinch grip following stroke
    Na Jin Seo
    William Z. Rymer
    Derek G. Kamper
    Experimental Brain Research, 2010, 202 : 891 - 901
  • [4] Altered phalanx force direction during power grip following stroke
    Leah R. Enders
    Na Jin Seo
    Experimental Brain Research, 2015, 233 : 1677 - 1688
  • [5] Effects of rTMS on grip force control following subcortical stroke
    Dafotakis, Manuel
    Grefkes, Christian
    Eickhoff, Simon B.
    Karbe, Hans
    Fink, Gereon R.
    Nowak, Dennis A.
    EXPERIMENTAL NEUROLOGY, 2008, 211 (02) : 407 - 412
  • [6] Impaired Force Control in Writer's Cramp Showing a Bilateral Deficit in Sensorimotor Integration
    Bleton, Jean-Pierre
    Teremetz, Maxime
    Vidailhet, Marie
    Mesure, Serge
    Maier, Marc A.
    Lindberg, Pavel G.
    MOVEMENT DISORDERS, 2014, 29 (01) : 130 - 134
  • [7] Impaired force control in writer's cramp showing a bilateral deficit in sensorimotor integration
    Bleton, J-P
    Teremetz, M.
    Vidailhet, M.
    Mesure, S.
    Maier, M. A.
    Lindberg, P.
    JOURNAL OF NEURAL TRANSMISSION, 2013, 120 (07) : 1139 - 1139
  • [8] SENSORIMOTOR CORTICAL CONTROL OF ISOMETRIC FORCE IN THE MONKEY
    HEPPREYMOND, MC
    WANNIER, TMJ
    MAIER, MA
    RUFENER, EA
    PROGRESS IN BRAIN RESEARCH, 1989, 80 : 451 - 463
  • [9] Clinical measures of handgrip limitation relate to impaired pinch grip force control after stroke
    Blennerhassett, Jannette M.
    Carey, Leeanne M.
    Matyas, Thomas A.
    JOURNAL OF HAND THERAPY, 2008, 21 (03) : 245 - 253
  • [10] Impaired attentional modulation of sensorimotor control and cortical excitability in schizophrenia
    Carment, Loic
    Dupin, Lucile
    Guedj, Laura
    Teremetz, Maxime
    Krebs, Marie-Odile
    Cuenca, Macarena
    Maier, Marc A.
    Amado, Isabelle
    Lindberg, Pavel G.
    BRAIN, 2019, 142 : 2149 - 2164