Sleep in multiple sclerosis: a systematic review and meta-analysis of polysomnographic findings

被引：5

作者：

Zhang, Ye ^{[1
,2
]}

Ren, Rong ^{[1
,2
,5
,6
]}

Yang, Linghui ^{[1
,2
]}

Zhang, Haipeng ^{[1
,2
]}

Shi, Yuan ^{[1
,2
]}

V. Vitiello, Michael ^{[3
]}

Sanford, Larry D. ^{[4
]}

Tang, Xiangdong ^{[1
,2
,5
,6
]}

机构：

[1] Sichuan Univ, Sleep Med Ctr, Mental Hlth Ctr, Translat Neurosci Ctr,Dept Resp & Crit Care Med, Chengdu, Peoples R China

[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China

[3] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA USA

[4] Eastern Virginia Med Sch, Ctr Integrat Neurosci & Inflammatory Dis Pathol &, Sleep Res Lab, Norfolk, VA USA

[5] Sichuan Univ, Sleep Med Ctr, Mental Hlth Ctr, Translat Neurosci Ctr,Dept Resp & Crit Care Med, Dian Xin Nan Jie 28, Chengdu 610041, Peoples R China

[6] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dian Xin Nan Jie 28, Chengdu 610041, Peoples R China

来源：

JOURNAL OF CLINICAL SLEEP MEDICINE | 2023年 / 19卷 / 02期

基金：

中国国家自然科学基金;

关键词：

multiple sclerosis; sleep; polysomnography; meta-analysis; FATIGUE; DISORDERS; DIAGNOSIS; ONSET; ADULTS; DAMAGE;

D O I：

10.5664/jcsm.10304

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study Objectives: This study aims to explore the polysomnographically measured sleep differences between patients with multiple sclerosis (MS) and healthy control patients. Methods: An electronic literature search was conducted in EMBASE, MEDLINE, all EBM databases, CINAHL, and PsycINFO from inception to March 2022. A random-effects model was applied to explore the pooled effect sizes of polysomnographic differences between patients with MS and control patients. Results: Thirteen studies were identified for meta-analysis. The meta-analyses revealed significant reductions in stage N2 sleep and sleep efficiency and increases in wake time after sleep onset, the periodic limb movement index, and the periodic limb movement arousal index in patients with MS compared with control patients. Meta-regression analyses showed that some of the heterogeneity was explained by age and daytime sleepiness of patients with MS. Conclusions: Our study showed that polysomnographic abnormalities are present in MS. Our findings also underscore the need for a comprehensive polysomnographic assessment of sleep changes in patients with MS. Furthermore, the effects of age and daytime sleepiness in patients with MS on sleep changes should also be carefully considered and closely monitored in the management of MS.

引用

页码：253 / 265

页数：13