Neurological Sequelae of COVID-19: A Biochemical Perspective

被引：0
|
作者：
Zhang, Xiaoxiao [1 ,2 ]
Zhang, Ying [3 ]
Wen, Ling [4 ]
Ouyang, Jess Lan [1 ]
Zhang, Weiwei [1 ]
Zhang, Jiaming [5 ]
Wang, Yuchuan [6 ]
Liu, Qiuyun [1 ]
机构：
[1] Sun Yat sen Univ, Sch Life Sci, Guangzhou 510275, Peoples R China
[2] Kunming Med Univ, Biomed Engn Res Ctr, Yunnan Key Lab Stem Cell & Regenerat Med, Kunming 650500, Peoples R China
[3] Guangzhou Ctr Dis Control & Prevent, Guangzhou 510440, Peoples R China
[4] Guangzhou Twelfth Peoples Hosp, GI Med, Guangzhou 510620, Guangdong, Peoples R China
[5] Sun Yat sen Univ, Sch Chem, Guangzhou 510275, Peoples R China
[6] North China Univ Sci & Technol, Sch Basic Med Sci, Tangshan 063210, Hebei, Peoples R China
来源：
ACS OMEGA | 2023年 / 8卷 / 31期
关键词：
CALCIUM; CRYSTALS; GLYCINE; PROTEIN; CANCER; ACIDS; ZINC;
D O I：
10.1021/acsomega.3c04100
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Exogenous factors can induce protein expression and modifytheproteome which sustains for a certain period of time. The proteinsof SARS-CoV-2 are high in valine plus glycine, which possess potentaffinity to divalent cations such as calcium. Calcium buildup changesthe protein expression profile by enabling the efficient synthesisof proteins rich in amino acids with calcium affinity. Subsequentformation of insoluble and stiff calcium oxalate and aggregates conferscellular stress and causes cell senescence. This scenario accountsfor sequelae seen in some patients following recovery from COVID-19.
引用
收藏
页码：27812 / 27818
页数：7
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