Breast Cancer: An Overview of Current Therapeutic Strategies, Challenge, and Perspectives

被引:24
|
作者
Wang, Jun [1 ]
Wu, San -Gang [2 ]
机构
[1] Sichuan Univ, West China Hosp, Canc Ctr, Dept Head & Neck Oncol, Chengdu, Sichuan, Peoples R China
[2] Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Radiat Oncol, Xiamen 361003, Peoples R China
来源
关键词
breast cancer; surgery; chemotherapy; radiotherapy; endocrine therapy; targeted therapy; immunotherapy; gene therapy; PATIENT-LEVEL METAANALYSIS; TERM-FOLLOW-UP; DOUBLE-BLIND; INTERNAL MAMMARY; ADJUVANT CHEMOTHERAPY; TRASTUZUMAB EMTANSINE; NEOADJUVANT TREATMENT; AROMATASE INHIBITORS; OVARIAN SUPPRESSION; CONSERVING SURGERY;
D O I
10.2147/BCTT.S432526
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer is the most commonly diagnosed cancer and the leading cause of death among female patients, which seriously threatens the health of women in the whole world. The treatments of breast cancer require the cooperation of a multidisciplinary setting and taking tumor load and molecular makers into account. For early breast cancer, breast-conserving surgery with radiotherapy or mastectomy alone remains the standard management, and the administration of adjuvant systemic therapy is decided by the status of lymph nodes, hormone receptors, and human epidermal growth factor receptor-2. For metastatic breast cancer, the goal of treatments is to prolong survival and maintain quality of life. This review will present the current advances and controversies of surgery, chemotherapy, radiotherapy, endocrine therapy, targeted therapy, immunotherapy, gene therapy, and other innovative treatment strategies in early-stage and metastatic breast cancer.
引用
收藏
页码:721 / 730
页数:10
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