Female Pattern Hair Loss: An Overview with Focus on the Genetics

被引：2

作者：

Ho, Chih-Yi ^{[1
]}

Chen, Jeff Yi-Fu ^{[2
]}

Hsu, Wen-Li ^{[3
]}

Yu, Sebastian ^{[3
]}

Chen, Wei-Chiao ^{[3
]}

Chiu, Szu-Hao ^{[3
]}

Yang, Hui-Ru ^{[4
]}

Lin, Sheng-Yao ^{[3
]}

Wu, Ching-Ying ^{[3
,5
]}

机构：

[1] Kaohsiung Med Univ, Coll Med, Sch Post Baccalaureate Med, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Kaohsiung Municipal Ta Tung Hosp, Coll Med,Dept Dermatol, Kaohsiung 801, Taiwan

[4] Kaohsiung Municipal Tatung Hosp, Dept Lab Med, Kaohsiung 801, Taiwan

[5] Chang Gung Univ Sci & Technol, Dept Cosmet Sci, Taoyuan 333, Taiwan

来源：

GENES | 2023年 / 14卷 / 07期

关键词：

female pattern hair loss; genetic factors; single nucleotide polymorphism (SNP); androgenetic alopecia; sex hormones; targeted gene therapy; MALE ANDROGENETIC ALOPECIA; SUSCEPTIBILITY LOCI; WOMEN; ASSOCIATION; POLYMORPHISMS; CYP19A1; VARIANTS; ETIOLOGY; CELLS;

D O I：

10.3390/genes14071326

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Pattern hair loss can occur in both men and women, and the underlying molecular mechanisms have been continuously studied in recent years. Male androgenetic alopecia (M-AGA), also termed male pattern hair loss, is the most common type of hair loss in men. M-AGA is considered an androgen-dependent trait with a background of genetic predisposition. The interplay between genetic and non-genetic factors leads to the phenotype of follicular miniaturization. Although this similar pattern of phenotypic miniaturization can also be found in female pattern hair loss (FPHL), the corresponding genetic factors in M-AGA do not account for the phenotype in FPHL, indicating that there are different genes contributing to FPHL. Therefore, the role of genetic factors in FPHL is still uncertain. Understanding the genetic mechanism that causes FPHL is crucial for the future development of personalized treatment strategies. This review aims to highlight the differences in the ethnic prevalence and genetic background of FPHL, as well as the current genetic research progress in nutrition, Wnt signaling, and sex hormones related to FPHL.

引用

页数：16

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