An in silico designed receptor antagonizing peptide targeting C-C motif chemokine receptor 8 attenuates monocyte/macrophage recruitment in vitro and in vivo

被引:0
|
作者
Geervliet, Eline [1 ,2 ]
Weiskirchen, Ralf [2 ]
Bansal, Ruchi [1 ]
机构
[1] Univ Twente, Med Cell Biophys, Enschede, Netherlands
[2] Rhein Westfal TH Aachen, Inst Mol Pathobiochem Expt Gene Therapy & Clin Ch, Aachen, Germany
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
FRI-394
引用
收藏
页码:S137 / S137
页数:1
相关论文
共 50 条
  • [1] Inhibition of C-C motif chemokine receptor 2 (CCR2) using a novel in silico designed peptide attenuates macrophage migration in vitro and intrahepatic monocyte recruitment in vivo
    Geervliet, Eline
    Weiskirchen, Ralf
    Bansal, Ruchi
    JOURNAL OF HEPATOLOGY, 2022, 77 : S400 - S400
  • [2] Antagonism of C-C motif chemokine receptor 2 (CCR2) using a novel in silico designed peptide attenuates macrophage infiltration and non-alcoholic steatohepatitis in vivo
    Geervliet, Eline
    Weiskirchen, Ralf
    Bansal, Ruchi
    JOURNAL OF HEPATOLOGY, 2023, 78 : S764 - S765
  • [3] Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice
    Heymann, Felix
    Hammerich, Linda
    Storch, Dunja
    Bartneck, Matthias
    Huss, Sebastian
    Ruesseler, Vanessa
    Gassler, Nikolaus
    Lira, Sergio A.
    Luedde, Tom
    Trautwein, Christian
    Tacke, Frank
    HEPATOLOGY, 2012, 55 (03) : 898 - 909
  • [4] Recent advances targeting C-C chemokine receptor type 2 for liver diseases in monocyte/macrophage
    Li, Min
    Chen, Liu
    Gao, Yue
    Li, Mengyuan
    Wang, Xiaosheng
    Qiang, Lei
    Wang, Xiaoping
    LIVER INTERNATIONAL, 2020, 40 (12) : 2928 - 2936
  • [5] C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain
    Winkler, Clayton W.
    Evans, Alyssa B.
    Carmody, Aaron B.
    Lack, Justin B.
    Woods, Tyson A.
    Peterson, Karin E.
    COMMUNICATIONS BIOLOGY, 2024, 7 (01)
  • [6] Identification of C-C chemokine receptor 1 (CCR1) as the monocyte hemofiltrate C-C chemokine (HCC)-1 receptor
    Tsou, CL
    Gladue, RP
    Carroll, LA
    Paradis, T
    Boyd, JG
    Nelson, RT
    Neote, K
    Charo, IF
    JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (03): : 603 - 608
  • [7] Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy
    Yang, S. J.
    IglayReger, H. B.
    Kadouh, H. C.
    Bodary, P. F.
    DIABETOLOGIA, 2009, 52 (05) : 972 - 981
  • [8] Neuronal/astrocytic expression of chemokine (C-C motif) ligand 2 is associated with monocyte/macrophage recruitment in male chronic pelvic pain
    Liu, Zhiqiang
    Murphy, Stephen F.
    Wong, Larry
    Schaeffer, Anthony J.
    Thumbikat, Praveen
    PAIN, 2020, 161 (11) : 2581 - 2591
  • [9] C-C motif chemokine receptor 2 as a novel intermediate in the ovulatory cascade
    Jaworski, J. P.
    Urrutia, M.
    Dascal, E.
    Jaita, G.
    Peluffo, M. C.
    MOLECULAR HUMAN REPRODUCTION, 2020, 26 (05) : 289 - 300
  • [10] C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury
    Wang, Xiangzi
    Niu, Xiaofei
    Wang, Yingkai
    Liu, Yang
    Yang, Cheng
    Chen, Xuyi
    Qi, Zhongquan
    NEURAL REGENERATION RESEARCH, 2025, 20 (08) : 2231 - 2244