Acute Genital Ulcers: When the Etiology Is Beyond the Obvious

This case study challenge describes the case of a 13-year-old female who presented to a primary care clinic with extremely painful vaginal lesions. She also had generalized symptoms such as fatigue, malaise, and low-grade fever. An adolescent with these presenting symptoms may make the nurse practitioner immediately consider the common sexually transmitted diseases often presented at primary and urgent care settings, yet there are many differentials that should be considered. Despite what might seem obvious, a thorough history, physical examination, and diagnostic testing are imperative to avoid misdiagnosis. (c) 2022 Elsevier Inc. All rights reserved.