Harnessing chitosan-adorned liposomes for enhanced drug delivery in cancer

被引:7
|
作者
Shaikh, Mohammad Arshad Javed [1 ,2 ]
Afzal, Obaid [3 ]
Almalki, Waleed Hassan [4 ]
Kazmi, Imran [5 ]
Alzarea, Sami I. [6 ]
Jafar, Mohammed [7 ]
Altamimi, Abdulmalik Saleh Alfawaz [3 ]
Jakhmola, Vikash [8 ]
Anand, Krishnan [9 ,10 ]
Singh, Sachin Kumar [11 ,12 ]
Dua, Kamal [12 ,13 ,15 ]
Gupta, Gaurav [1 ,14 ]
机构
[1] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur 302017, India
[2] TPCTs Coll Engn, Dept Pharm, Osmanabad, Maharashtra, India
[3] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj 11942, Saudi Arabia
[4] Umm Al Qura Univ, Coll Pharm, Dept Pharmacol, Mecca, Saudi Arabia
[5] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia
[6] Jouf Univ, Coll Pharm, Dept Pharmacol, Sakaka, Saudi Arabia
[7] Imam Abdulrahman Bin Faisal Univ, Coll Clin Pharm, Dept Pharmaceut, POB 1982, Dammam 34212, Saudi Arabia
[8] Uttaranchal Univ, Uttaranchal Inst Pharmaceut Sci, Dehra Dun 248007, India
[9] Univ Free State, Fac Hlth Sci, Sch Pathol, Dept Chem Pathol, Bloemfontein, South Africa
[10] Univ Free State, Natl Hlth Lab Serv, Bloemfontein, South Africa
[11] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India
[12] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia
[13] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW 2007, Australia
[14] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll, Dept Pharmacol, Chennai, India
[15] Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, India
关键词
Cancer; Chitosan; Liposomes; Drug delivery; Immunotherapy; CO-DELIVERY; POLYMERIC LIPOSOMES; NANOPARTICLES; ERLOTINIB; NANOLIPOSOMES; DOXORUBICIN; ANTICANCER; COMPLEXES; EFFICACY; SYSTEM;
D O I
10.1016/j.jddst.2023.104619
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cancer is a progressive disease that is caused by a combination of factors, including one's genetics, environment, and lifestyle choices. The pillars of cancer management include chemotherapy, surgical procedures, and radia-tion therapy; however, a wide variety of therapeutic combinations involving these and other therapies are also utilised. Despite its low success rate, chemotherapy remains the standard gold treatment. Drug carrier systems have been developed to address major challenges such as poor drug penetration and resistance. Future drug delivery systems should be based on chitosan liposomes because of their advantages, versatility, and ease of manufacture. In this article, we'll look at how liposomes based on chitosan can be used to treat several types of cancer through several different routes. Liposomes have been used in immunotherapy, and they can be engi-neered to respond to photothermal therapy as well as chemotherapeutic medicines and targeted agents.
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页数:9
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