Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment

被引：10
|
作者：
Parsons, Joshua. B. [1 ,2 ]
Westgeest, Annette. C. [1 ,3 ]
Conlon, Brian. P. B. [2 ]
Fowler, Vance. G., Jr. [1 ,4 ]
机构：
[1] Duke Univ Med Ctr, Dept Med, Div Infect Dis, Durham, NC 27710 USA
[2] Univ North Carolina Chapel Hill, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
[3] Leiden Univ Med Ctr, Dept Infect Dis, NL-2333 ZA Leiden, Netherlands
[4] Duke Clin Res Inst, Durham, NC 27710 USA
来源：
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Staphylococcus aureus; persistent bacteremia; MRSA; PLATELET MICROBICIDAL PROTEIN; IN-VITRO RESISTANCE; MINIMUM INHIBITORY CONCENTRATION; BLOOD-STREAM INFECTIONS; CLINICAL-FEATURES; EXPERIMENTAL ENDOCARDITIS; VANCOMYCIN TOLERANCE; AGR DYSFUNCTION; MRSA BACTEREMIA; GENOTYPIC-CHARACTERISTICS;
D O I：
10.3390/antibiotics12030455
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Methicillin-resistant Staphylococcus aureus (MRSA) is a devastating pathogen responsible for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its ability to persist in the bloodstream for several days despite seemingly appropriate antibiotics. Persistent MRSA bacteremia is common and is associated with poor clinical outcomes. The etiology of persistent MRSA bacteremia is a result of the complex interplay between the host, the pathogen, and the antibiotic used to treat the infection. In this review, we explore the factors related to each component of the host-pathogen interaction and discuss the clinical relevance of each element. Next, we discuss the treatment options and diagnostic approaches for the management of persistent MRSA bacteremia.
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页数：21
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