The role of metabolic reprogramming of tumor-associated macrophages in shaping the immunosuppressive tumor microenvironment

被引：11
|
作者：
Li, Lunxu [1 ]
Tian, Yu [1 ]
机构：
[1] China Med Univ, Dept Gen Surg, Shengjing Hosp, Shenyang, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 161卷
关键词：
Tumor-associated macrophage; Tumor microenvironment; Metabolism; Immunosuppression; NF-KAPPA-B; ACID-BINDING PROTEIN; REGULATORY T-CELLS; SUCCINATE-DEHYDROGENASE; TRYPTOPHAN-METABOLISM; MYELOID CELLS; NITRIC-OXIDE; TCA CYCLE; INDOLEAMINE 2,3-DIOXYGENASE; HEPATOCELLULAR-CARCINOMA;
D O I：
10.1016/j.biopha.2023.114504
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Macrophages are potent immune effector cells in innate immunity and exert dual-effects in the tumor micro -environment (TME). Tumor-associated macrophages (TAMs) make up a significant portion of TME immune cells. Similar to M1/M2 macrophages, TAMs are also highly plastic, and their functions are regulated by cytokines, chemokines and other factors in the TME. The metabolic changes in TAMs are significantly associated with polarization towards a protumour or antitumour phenotype. The metabolites generated via TAM metabolic reprogramming in turn promote tumor progression and immune tolerance. In this review, we explore the metabolic reprogramming of TAMs in terms of energy, amino acid and fatty acid metabolism and the potential roles of these changes in immune suppression.
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页数：14
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