Healthcare center clustering for Cox's proportional hazards model by fusion penalty

被引:3
|
作者
Liu, Lili [1 ,2 ]
He, Kevin [3 ]
Wang, Di [3 ]
Ma, Shujie [4 ]
Qu, Annie [5 ]
Lin, Lu [6 ]
Miller, J. Philip [1 ]
Liu, Lei [1 ]
机构
[1] Washington Univ St Louis, Div Biostat, St Louis, MO 63130 USA
[2] Shandong Univ, Res Ctr Math & Interdisciplinary Sci, Qingdao, Peoples R China
[3] Univ Michigan, Dept Biostat, Ann Arbor, MI USA
[4] Univ Calif Riverside, Dept Stat, Riverside, CA USA
[5] Univ Calif Irvine, Dept Stat, Irvine, CA USA
[6] Shandong Univ, Zhongtai Secur Inst Financial Studies, Jinan, Peoples R China
基金
中国博士后科学基金;
关键词
fixed effects; fusion penalty; latent class; provider profiling; random effects; VARIABLE SELECTION; OUTCOMES; KIDNEY;
D O I
10.1002/sim.9825
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
There has been growing research interest in developing methodology to evaluate healthcare centers' performance with respect to patient outcomes. Conventional assessments can be conducted using fixed or random effects models, as seen in provider profiling. We propose a new method, using fusion penalty to cluster healthcare centers with respect to a survival outcome. Without any prior knowledge of the grouping information, the new method provides a desirable data-driven approach for automatically clustering healthcare centers into distinct groups based on their performance. An efficient alternating direction method of multipliers algorithm is developed to implement the proposed method. The validity of our approach is demonstrated through simulation studies, and its practical application is illustrated by analyzing data from the national kidney transplant registry.
引用
收藏
页码:3685 / 3698
页数:14
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