Role of mechanotransduction on decision making for treatment of chronic wounds

被引:0
|
作者
Mcelvain, Kelly [1 ]
Gopalakrishnan, Sandeep [2 ]
Dabagh, Mahsa [1 ]
机构
[1] Univ Wisconsin Milwaukee, Dept Psychol, Milwaukee, WI 53211 USA
[2] Univ Wisconsin Milwaukee, Coll Nursing, Milwaukee, WI USA
关键词
chronic wound; computational modeling; mechanotransduction; tissue engineering; wound dressing; wound healing; wound tissue; MECHANICAL-PROPERTIES; MODEL; ANGIOGENESIS; INFLAMMATION; MANAGEMENT; IMPACT; MOIST; WET; DRY;
D O I
10.1002/aic.18390
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The objective of this study is to take an initial step to determine and interpret the extents to which biophysical wound dressing properties impact mechanotransduction within a wound tissue. Current experimental techniques make it challenging to investigate many of the complexities of the wound healing process. Thus, the purpose of this study is to begin with computational models and theoretical descriptions that propose predictions and explanations of the role of various mechanical wound dressing characteristics on mechanotransduction in wound tissues. Three-dimensional models of wound tissue and wound dressings have been developed to analyze how von Mises stresses are distributed within the tissue models. Our results show that shorter ellipsoid dressings lead to highest stresses within the wound tissue where dressing's thickness and stiffness don't show a significant impact. When using a rectangular dressing, shorter, softer, thinner ones lead to high stress transmission to a wound tissue.
引用
收藏
页数:11
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