Genomic landscapes to characterize mismatch-repair deficiency (dMMR)/microsatellite instability-high (MSI-H) gastrointestinal (GI) cancers stratified by tumor mutation burden (TMB)

被引：0
|
作者：
Wang, Jingyuan
Xiu, Joanne
Farrell, Alex Patrick
Battaglin, Francesca
Arai, Hiroyuki
Millstein, Joshua
Soni, Shivani
Zhang, Wu
Shields, Anthony F.
Grothey, Axel
Weinberg, Benjamin Adam
Marshall, John
Lou, Emil
Khushman, Moh'd M.
Sohal, Davendra
Hall, Michael J.
Oberley, Matthew James
Spetzler, David
Lenz, Heinz-Josef
机构：
[1] Univ Southern Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA
[2] Caris Life Sci, Phoenix, AZ USA
[3] Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA
[4] Keck Sch Med, Div Med Oncol, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA
[5] Barbara Ann Karmanos Canc Inst, Detroit, MI USA
[6] West Canc Ctr, Germantown, TN USA
[7] Georgetown Univ, Med Ctr, Washington, DC USA
[8] Georgetown Univ, Ruesch Ctr Cure Gastrointestinal Canc, Lombardi Comprehens Canc Ctr, Washington, DC USA
[9] Univ Minnesota, Minneapolis, MN USA
[10] Washington Univ St Louis, Siteman Canc Ctr, St Louis, MO USA
[11] Univ Cincinnati, Cincinnati, OH USA
[12] Fox Chase Canc Ctr, Philadelphia, PA USA
[13] Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2023年 / 41卷 / 16期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2618
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Clinicopathological and genomic characteristics of DNA Mismatch Repair-Deficient (dMMR) and microsatellite instability-high (MSI-H) resected gastric adenocarcinoma
    Zhou, J.
    Liang, B.
    Yin, M.
    Zhang, H.
    Liu, F.
    Dong, L.
    Zhang, B.
    Xu, Y.
    [J]. ANNALS OF ONCOLOGY, 2020, 31 : S921 - S922
  • [2] Prevalence of high tumor mutational burden (TMB-H) and microsatellite instability-high (MSI-H) status in neuroendocrine neoplasms
    Padda, Sukhmani Kaur
    Aggarwal, Rahul Raj
    Ashok, Arya
    Mauer, Elizabeth
    Shirazi, Maryam
    Bergsland, Emily K.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [3] Comparative molecular analysis between microsatellite instability-high (MSI-H) tumors with high tumor mutational burden (TMB-H) versus MSI-H tumors with TMB-intermediate/low
    Salem, M. E.
    Puccini, A.
    Grothey, A.
    Xiu, J.
    Goldberg, R.
    Kim, E. S.
    Korn, W. M.
    Lenz, H-J.
    Raghavan, D.
    Marshall, J. L.
    Hall, M. J.
    [J]. ANNALS OF ONCOLOGY, 2018, 29
  • [4] Initial findings from the DREAM-GI national database: Assessing the efficacy and safety of neoadjuvant immunotherapy (NIT) in patients with deficient mismatch repair/microsatellite instability-high (dMMR/MSI-H) gastrointestinal (GI) cancer.
    Chakrabarti, Sakti
    Selfridge, J. Eva
    Parish, Marie
    Bajor, David L.
    Ruggeri, Antony
    Tolay, Sameer
    Conces, Madison
    Lumish, Melissa Amy
    Mohamed, Amr
    Mahipal, Amit
    Shreenivas, Aditya V.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (3_SUPPL) : 736 - 736
  • [5] Real-world efficacy and safety of immune checkpoint inhibitors (ICI) in gastrointestinal tumors with mismatch repair deficiency or microsatellite instability (dMMR/MSI-H)
    Martinez Lago, N.
    Cousillas, A.
    Jara, P.
    Reboredo Lopez, M.
    Gonzalez Villarroel, P.
    Covela, M.
    Lopez, C.
    Grana Suarez, B.
    Gallardo Martin, E.
    de la Camara Gomez, J.
    Garcia Lorenzo, C.
    Lopez Jato, C.
    Carral Maseda, A.
    Fernandez Montes, A.
    Rivera Herrero, F.
    [J]. ANNALS OF ONCOLOGY, 2024, 35 : S206 - S206
  • [6] SYSTEMATIC AND STRUCTURED REVIEWS OF THE DISEASE BURDEN IN PATIENTS WITH MICROSATELLITE INSTABILITY HIGH (MSI-H) OR MISMATCH REPAIR DEFICIENT (DMMR) COLORECTAL CANCER (CRC)
    Amonkar, M.
    Chase, M.
    Takyar, J.
    Sharma, S.
    [J]. VALUE IN HEALTH, 2021, 24 : S24 - S24
  • [7] Determination of Eligibility for Pembrolizumab Treatment: Comparison of Mismatch Repair Deficiency (dMMR) by IHC, Microsatellite Instability-High (MSI-H) Status by PCR, and MMR Gene Mutations (MMRmut) by NGS
    Yang, Richard
    Ronaghy, Arash
    Abdulrazzaq, Mustafa
    Feinstein, Galina
    Routbort, Mark
    Kopetz, Scott
    Broaddus, Russell
    Prieto, Victor
    Medeiros, L. Jeffrey
    Luthra, Rajyalakshmi
    Patel, Keyur
    [J]. MODERN PATHOLOGY, 2020, 33 (SUPPL 2) : 838 - 839
  • [8] Epidemiology of Microsatellite Instability High (MSI-H) and Deficient Mismatch Repair (dMMR) in Solid Tumors: A Structured Literature Review
    Lorenzi, Maria
    Amonkar, Mayur
    Zhang, Jacky
    Mehta, Shivani
    Liaw, Kai-Li
    [J]. JOURNAL OF ONCOLOGY, 2020, 2020
  • [9] Determination of Eligibility for Pembrolizumab Treatment: Comparison of Mismatch Repair Deficiency (dMMR) by IHC, Microsatellite Instability-High (MSI-H) Status by PCR, and MMR Gene Mutations (MMRmut) by NGS
    Yang, Richard
    Ronaghy, Arash
    Abdulrazzaq, Mustafa
    Feinstein, Galina
    Routbort, Mark
    Kopetz, Scott
    Broaddus, Russell
    Prieto, Victor
    Medeiros, L. Jeffrey
    Luthra, Rajyalakshmi
    Patel, Keyur
    [J]. LABORATORY INVESTIGATION, 2020, 100 (SUPPL 1) : 838 - 839
  • [10] Impact of RAS mutations on immunologic characteristics of the tumor microenvironment (TME) in patients with microsatellite instability-high (MSI-H) or mismatch-repair-deficient (dMMR) colorectal cancer (CRC).
    Salem, Mohamed E.
    Andre, Thierry
    El-Refai, Sherif Mohamed
    Kopetz, Scott
    Tabernero, Josep
    Sinicrope, Frank A.
    Tie, Jeanne
    George, Thomas J.
    VanCutsem, Eric
    Mauer, Elizabeth
    Lonardi, Sara
    Overman, Michael J.
    Foureau, David
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
12345