GSK2795039 a novel NOX2 inhibitor, reduces proinflammatory microglial activation in vitro and in a model of traumatic brain injury

被引：0
|
作者：
Laabei, Janeen [1 ]
Loane, David [1 ]
机构：
[1] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin, Ireland
来源：
JOURNAL OF NEUROCHEMISTRY | 2023年 / 166卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A 03-13
引用
收藏
页码：39 / 40
页数：2
相关论文
共 50 条
  • [1] Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor
    Hirano, Kazufumi
    Chen, Woei Shin
    Chueng, Adeline L. W.
    Dunne, Angela A.
    Seredenina, Tamara
    Filippova, Aleksandra
    Ramachandran, Sumitra
    Bridges, Angela
    Chaudry, Laiq
    Pettman, Gary
    Allan, Craig
    Duncan, Sarah
    Lee, Kiew Ching
    Lim, Jean
    Ma, May Thu
    Ong, Agnes B.
    Ye, Nicole Y.
    Nasir, Shabina
    Mulyanidewi, Sri
    Aw, Chiu Cheong
    Oon, Pamela P.
    Liao, Shihua
    Li, Dizheng
    Johns, Douglas G.
    Miller, Neil D.
    Davies, Ceri H.
    Browne, Edward R.
    Matsuoka, Yasuji
    Chen, Deborah W.
    Jaquet, Vincent
    Rutter, A. Richard
    ANTIOXIDANTS & REDOX SIGNALING, 2015, 23 (05) : 358 - 374
  • [2] NOX2 oxidase inhibitor GSK2795039 possess antiviral activity against H1N1 influenza A virus in vitro and vivo
    Xue, Ning
    Wang, Lirong
    Wang, Bin
    Hu, Jianhe
    Zhang, Shouping
    MICROBIAL PATHOGENESIS, 2023, 174
  • [3] Selective Pharmacological Inhibition of NOX2 by GSK2795039 Improves Bladder Dysfunction in Cyclophosphamide-Induced Cystitis in Mice
    de Oliveira, Mariana G.
    Monica, Fabiola Z.
    Passos, Gabriela R.
    Victorio, Jamaira A.
    Davel, Ana Paula
    Oliveira, Anna Lethicia Lima
    Parada, Carlos A.
    D'Ancona, Carlos A. L.
    Hill, Warren G.
    Antunes, Edson
    ANTIOXIDANTS, 2023, 12 (01)
  • [4] Establishment and Application of a Novel In Vitro Model of Microglial Activation in Traumatic Brain Injury
    Liu, Ning
    Li, Yadan
    Jiang, Yinghua
    Shi, Samuel
    Niamnud, Aim
    Vodovoz, Sammy J.
    Katakam, Prasad V. G.
    Vidoudez, Charles
    Dumont, Aaron S.
    Wang, Xiaoying
    JOURNAL OF NEUROSCIENCE, 2023, : 319 - 332
  • [5] NADPH oxidase (NOX2)-mediated regulation of microglial NLRP3 inflammasome activation in traumatic brain injury
    Laabei, Janeen
    Vegliante, Gloria
    Strogulski, Nathan Ryzewski
    Threja, Sahil
    Douglas, Carly
    Hanscom, Marie
    Pearson, Andrew
    Nkiliza, Aurore
    Ojo, Joseph
    Loane, David
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 1369 - 1369
  • [6] Microglial NOX2 as a therapeutic target in traumatic brain injury: Mechanisms, consequences, and potential for neuroprotection
    Bano, Nargis
    Khan, Sameera
    Ahamad, Shakir
    Dar, Nawab John
    Alanazi, Hamad H.
    Nazir, Aamir
    Bhat, Shahnawaz Ali
    AGEING RESEARCH REVIEWS, 2025, 108
  • [7] NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury
    Kumar, Alok
    Barrett, James P.
    Alvarez-Croda, Dulce-Mariely
    Stoica, Bogdan A.
    Faden, Alan I.
    Loane, David J.
    BRAIN BEHAVIOR AND IMMUNITY, 2016, 58 : 291 - 309
  • [8] NOX2 REGULATION OF MICROGLIAL ACTIVATION IN THE TBI BRAIN: A NOVEL MECHANISM FOR NEURO-PROTECTION AND POST-TRAUMATIC REPAIR
    Loane, David
    Barrett, James
    Alvarez, Mariely
    Stoica, Bogdan
    Tchantchou, Flaubert
    Faden, Alan
    Kumar, Alok
    JOURNAL OF NEUROTRAUMA, 2015, 32 (12) : A94 - A94
  • [9] MICROGLIAL ACTIVATION IN A RAT MODEL OF PEDIATRIC TRAUMATIC BRAIN INJURY
    Robertson, Courtney
    Saraswati, Manda
    Balakrishnan, Bindu
    Kannan, Sujatha
    JOURNAL OF NEUROTRAUMA, 2012, 29 (10) : A75 - A75
  • [10] Inhibition of NOX2 contributes to the therapeutic effect of aloin on traumatic brain injury
    Dong, Haihai
    Wang, Haitao
    Zhang, Xuezhi
    FOLIA NEUROPATHOLOGICA, 2020, 58 (03) : 265 - 274
12345