Non-canonical Wnt signaling in the eye

被引：11

作者：

Shah, Ruchi ^{[1
,2
]}

Amador, Cynthia ^{[1
,2
]}

Chun, Steven T. ^{[1
,2
,3
]}

Ghiam, Sean ^{[1
,2
,4
]}

Saghizadeh, Mehrnoosh ^{[1
,2
,5
]}

Kramerov, Andrei A. ^{[1
,2
]}

Ljubimov, Alexander, V ^{[6
,7
]}

机构：

[1] Cedars Sinai Med Ctr, Biomed Sci, Los Angeles, CA USA

[2] Cedars Sinai Med Ctr, Regenerat Med Inst Eye Program, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Los Angeles, CA USA

[4] Tel Aviv Univ, New York State Amer Program, Sackler Sch Med, Tel Aviv, Israel

[5] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA

[6] Cedars Sinai Med Ctr, Neurosurg, Los Angeles, CA USA

[7] Cedars Sinai Med Ctr, UCLA Sch Med, Regenerat Med Inst Eye Program, 8700 Beverly Blvd, AHSP-A8319, Los Angeles, CA 90048 USA

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2023年 / 95卷

关键词：

Planar cell polarity; Calcium signaling; Wnt signaling; Eye development; Eye diseases; Cornea; Retina; Lens; Conjunctiva; Stem cells; PLANAR CELL POLARITY; CORNEAL EPITHELIAL-CELLS; CONGENITAL ANIRIDIA; STEM-CELLS; PATHOGENIC ROLE; BETA-CATENIN; EXPRESSION; PATHWAY; GENE; KERATOCONUS;

D O I：

10.1016/j.preteyeres.2022.101149

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Wnt signaling comprises a group of complex signal transduction pathways that play critical roles in cell proliferation, differentiation, and apoptosis during development, as well as in stem cell maintenance and adult tissue homeostasis. Wnt pathways are classified into two major groups, canonical (& beta;-catenin-dependent) or noncanonical (& beta;-catenin-independent). Most previous studies in the eye have focused on canonical Wnt signaling, and the role of non-canonical signaling remains poorly understood. Additionally, the crosstalk between canonical and non-canonical Wnt signaling in the eye has hardly been explored. In this review, we present an overview of available data on ocular non-canonical Wnt signaling, including developmental and functional aspects in different eye compartments. We also discuss important changes of this signaling in various ocular conditions, such as keratoconus, aniridia-related keratopathy, diabetes, age-related macular degeneration, optic nerve damage, pathological angiogenesis, and abnormalities in the trabecular meshwork and conjunctival cells, and limbal stem cell deficiency.

引用

页数：13

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