Laser photostability of chitosan coated gold-GO nanocomposite and its role as a nano-therapeutic agent for control breast cancer growth

被引：4

作者：

Ramadan, Marwa A. ^{[1
]}

Gad, Sara ^{[2
]}

Sharaky, Marwa ^{[3
,4
]}

Faid, Amna H. ^{[5
]}

机构：

[1] Cairo Univ CU, Natl Inst Laser Enhanced Sci NILES, Dept Laser Applicat Metrol Photochem & Agr, Giza, Egypt

[2] City Sci Res & Technol Applicat SRTA City, Adv Technol & New Mat Res Inst, Elect Mat Res Dept, Alexandria, Egypt

[3] Cairo Univ, Natl Canc Inst, Canc Biol Dept, Pharmacol Unit, Cairo, Egypt

[4] Ahram Canadian Univ, Fac Pharm, Biochem Dept, Giza, Egypt

[5] Cairo Univ, Natl Inst Laser Enhanced Sci, Dept Laser Sci & Interact, Cairo 12613, Egypt

来源：

DISCOVER APPLIED SCIENCES | 2024年 / 6卷 / 04期

关键词：

Chitosan coated AuNPs; GO/Au nanocomposite; Laser photostability; Raman spectroscopy; Breast cancer cell lines; GRAPHENE OXIDE; NANOPARTICLES; SILVER; OXIDATION; FACILE; ASSAY;

D O I：

10.1007/s42452-024-05808-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background As the global cancer burden increases, it is critical to develop alternative treatments that produce minimal side effects, owing to its optical, thermal, and biological anticancer and biomedical applications of graphene and its nanocomposites. researchers have devoted the past few years to developing graphene/polymer and graphene/metal nanocomposites.Materials and methods Here a simple, highly stable, non-toxic, eco- friendly chitosan gold nanoparticles (Cs-AuNPs) and its nanocomposites with graphene oxide nanosheets (GO) to form novel photostable (GO/AuNPs) nanocomposites. The prepared nanomaterials were characterized by UV-Vis, FTIRs, TEM and Raman as shown in graphical abstract. In addition, the anticancer efficiency of the prepared nanomaterials in breast cell lines (MCF7, T47D, MDA-MB-468 and MDA-MB-231) using SRP assay were evaluated.Results Results revealed that Cs-AuNPs bound with the GO sheets via electrostatic interaction with high stability with uniform decoration. A new FTIRs peak of high intensity was found in the GO/Au nanocomposite confirming the decoration of Cs-AuNPs on the surface of the GO layers. GO/Au nanocomposite has a significant cytotoxic effect on breast cell lines as compared to GO only.Conclusion This work opens perceptions for translational applications of GO/Au nanocomposite on cancer cell lines, future work is to use the prepared nanocomposite in photothermal chemotherapy combined treatment. Chitosan reduced gold nanoparticles were successfully prepared and incorporated on graphene oxide nanosheets. Chitosan reduced gold nanoparticles reduce the viability of the cell population after 48h exposure with the lower 50 percentage viability concentration. Incorporation of Chitosan reduced gold nanoparticles on graphene oxide enhance the cytotoxic effect of graphene oxide consequently graphene oxide / gold nanoparticles nanocomposite has a significant cytotoxicity effective against all tested breast cancer cells.

引用

页数：12