Strategies toward Metal-Free Carbon Monoxide Prodrugs: An Update

被引：9
|
作者：
Min, Qingqiang [1 ]
Ji, Xingyue [1 ]
机构：
[1] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215021, Jiangsu, Peoples R China
来源：
CHEMMEDCHEM | 2023年 / 18卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Carbon monoxide; Drug delivery; Gasotransmitters; Metal-free; Prodrugs; ISCHEMIA-REPERFUSION INJURY; NITRIC-OXIDE; ISCHEMIA/REPERFUSION INJURY; GASOTRANSMITTER PRODRUGS; CARDIOPULMONARY BYPASS; INFLAMMATORY RESPONSE; CHEMICAL STRATEGY; RELEASE; MOLECULE; CLICK;
D O I：
10.1002/cmdc.202200500
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Carbon monoxide is an important gasotransmitter in mammals, with pleiotropic therapeutic potential against a wide range of human diseases. However, clinical translation of CO is severely hampered by the lack of a reliable CO delivery form. The development of metal-free CO prodrugs is the key to resolving such delivery issues. Over the past three years, some new exciting progress has been made in this field. In this review, we highlight these advances and discuss related issues.
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页数：11
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