The Tumor Immune Microenvironment in Cutaneous Squamous Cell Carcinoma Arising in Organ Transplant Recipients

被引：3
|
作者：
Zilberg, Catherine [1 ,5 ]
Lyons, James Guy [2 ]
Gupta, Ruta [3 ]
Ferguson, Angela [2 ]
Damian, Diona Lee [1 ,4 ]
机构：
[1] Univ Sydney, Royal Prince Alfred Hosp, Dept Dermatol, Sydney, Australia
[2] Univ Sydney, Centenary Inst, Sydney, Australia
[3] Royal Prince Alfred Hosp, Dept Tissue Pathol & Diagnost Oncol, NSW Hlth Pathol, Sydney, Australia
[4] Melanoma Inst Australia, Sydney, Australia
[5] Univ Sydney, Royal Prince Alfred Hosp, Dept Dermatol, Missenden Rd, Sydney, NSW 2050, Australia
来源：
ANNALS OF DERMATOLOGY | 2023年 / 35卷 / 02期
关键词：
Carcinoma; Skin neoplasms; Squamous cell; Transplantation immunology; CD8(+) T-CELLS; SKIN-CANCER; IMMUNOSUPPRESSED PATIENTS; RISK-FACTORS; EXPRESSION; LESIONS; INFILTRATION; MACROPHAGES; SURVIVAL; PD-L1;
D O I：
10.5021/ad.22.175
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Cutaneous squamous cell carcinoma (cSCC) is the most common malignancy in immune -suppressed organ transplant recipients (OTRs). Whilst rates of other malignancies (both cutaneous and non-cutaneous) are elevated in this population, the increase is far less strik-ing. This suggests that cSCC must be a highly immunogenic tumor. The tumor immune microenvironment is altered in cSCC from OTRs. It has reduced anti-tumor properties and instead provides an environment that facilitates tumor growth and survival. Understand-ing the composition and function of the tumor immune microenvironment in cSCC from OTRs is useful for prognostication and therapeutic decisions.
引用
收藏
页码：91 / 99
页数：9
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