Iodine-Promoted Transamidation of N,N-Dimethylacetamide (DMA) with Amines

被引：0
|
作者：
Ma, Haojie [1 ]
Zhou, Fengyuan [1 ]
Su, Fanwen [1 ]
Han, Bo [1 ]
Li, Ran [1 ]
Zhang, Yuqi [1 ]
Wang, Jijiang [1 ]
机构：
[1] Yanan Univ, Coll Chem & Chem Engn, Key Lab New Energy & New Funct Mat, Shaanxi Key Lab Chem React Engn, Yanan 716000, Shaanxi, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 11期
基金：
中国国家自然科学基金;
关键词：
iodine; N-acylation; transamidation; N; N-dimethylacetamide; acetamide; CATALYZED N-FORMYLATION; CARBOXYLIC-ACIDS; SULFURIC-ACID; METAL-FREE; AMIDE; ACYLATION; AMIDATION; INHIBITOR; CHLORIDE;
D O I：
10.6023/cjoc202304022
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and convenient transamidation of N,N-dimethylacetamide (DMA) with amines for the synthesis of acetamides with moderate to excellent yields is reported. Low-cost I-2 is used as efficient promoter for this transformation. Furthermore, the reaction has simple conditions, good functional group tolerance, substrates without prefunctionalization, and practicality, which can be widely used in the synthesis of acetamide drugs and biologically active molecules.
引用
收藏
页码：3960 / 3965
页数：6
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