Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides

被引：5

作者：

Wang, Yue ^{[1
]}

Yu, Yanbo ^{[1
,2
,3
]}

Li, Lixiang ^{[1
,2
,3
]}

Zheng, Mengqi ^{[1
]}

Zhou, Jiawei ^{[1
]}

Gong, Haifan ^{[4
]}

Feng, Bingcheng ^{[1
]}

Wang, Xiao ^{[5
]}

Meng, Xuanlin ^{[6
,7
]}

Cui, Yanyan ^{[8
]}

Xia, Yanan ^{[1
]}

Chu, Shuzheng ^{[8
]}

Lin, Lin ^{[1
]}

Chang, Huijun ^{[1
]}

Zhou, Ruchen ^{[1
]}

Ma, Mingjun ^{[1
]}

Li, Zhen ^{[1
,2
,3
]}

Ji, Rui ^{[1
,2
,3
]}

Lu, Ming ^{[9
]}

Yang, Xiaoyun ^{[1
,2
,3
]}

Zuo, Xiuli ^{[1
,2
,3
]}

Li, Shiyang ^{[1
,8
,10
]}

Li, Yanqing ^{[1
,2
,3
]}

机构：

[1] Shandong Univ, Dept Gastroenterol, Qilu Hosp, Jinan, Peoples R China

[2] Shandong Univ, Lab Translat Gastroenterol, Qilu Hosp, Jinan, Peoples R China

[3] Shandong Prov Clin Res Ctr Digest Dis, Jinan, Peoples R China

[4] Sun Yat Sen Univ, Sch Comp Sci & Engn, Guangzhou, Peoples R China

[5] Shandong Univ, Dept Pathol, Qilu Hosp, Jinan, Peoples R China

[6] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Shanghai, Peoples R China

[7] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai, Peoples R China

[8] Shandong Univ, Adv Med Res Inst, Jinan, Peoples R China

[9] Shandong Univ, Clin Epidemiol Unit, Qilu Hosp, Jinan, Peoples R China

[10] Shandong Univ, Key Lab Expt Teratol, Minist Educ, Jinan, Peoples R China

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

关键词：

FARNESOID X RECEPTOR; PANETH CELLS; WNT; EXPRESSION; LANDSCAPE; DEFENSE; DISEASE;

D O I：

10.1038/s41467-023-40565-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wang et al. clarify the regional heterogeneity of intestinal AMPs and identify that chromatin accessibility determines the potential of BATFs to regulate AMPs at the pre-transcriptional level, thus shaping the regional heterogeneity of AMPs. Antimicrobial peptides (AMPs) are important mediators of intestinal immune surveillance. However, the regional heterogeneity of AMPs and its regulatory mechanisms remain obscure. Here, we clarified the regional heterogeneity of intestinal AMPs at the single-cell level, and revealed a cross-lineages AMP regulation mechanism that bile acid dependent transcription factors (BATFs), NR1H4, NR1H3 and VDR, regulate AMPs through a ligand-independent manner. Bile acids regulate AMPs by perturbing cell differentiation rather than activating BATFs signaling. Chromatin accessibility determines the potential of BATFs to regulate AMPs at the pre-transcriptional level, thus shaping the regional heterogeneity of AMPs. The BATFs-AMPs axis also participates in the establishment of intestinal antimicrobial barriers of fetuses and the defects of antibacterial ability during Crohn's disease. Overall, BATFs and chromatin accessibility play essential roles in shaping the regional heterogeneity of AMPs at pre- and postnatal stages, as well as in maintenance of antimicrobial immunity during homeostasis and disease.

引用

页数：16

共 9 条

[1] Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides
Yue Wang
Yanbo Yu
Lixiang Li
Mengqi Zheng
Jiawei Zhou
Haifan Gong
Bingcheng Feng
Xiao Wang
Xuanlin Meng
Yanyan Cui
Yanan Xia
Shuzheng Chu
Lin Lin
Huijun Chang
Ruchen Zhou
Mingjun Ma
Zhen Li
Rui Ji
Ming Lu
Xiaoyun Yang
Xiuli Zuo
Shiyang Li
Yanqing Li
Nature Communications, 14 (1)
[2] EFFECT OF SPERMINE ON TRANSCRIPTION OF MAMMALIAN CHROMATIN BY MAMMALIAN DEOXYRIBONUCLEIC ACID-DEPENDENT RIBONUCLEIC-ACID POLYMERASE
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TADOLINI, B
BIOCHEMICAL JOURNAL, 1975, 146 (03) : 697 - 703
[3] REGULATION OF THE GENE ENCODING THE INTESTINAL BILE ACID TRANSPORTER ASBT BY CDX TRANSCRIPTION FACTORS
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Eloranta, J. J.
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[4] Regulation of the Gene Encoding the Intestinal Bile Acid Transporter ASBT by CDX Transcription Factors
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[5] Identification of Abscisic Acid-Dependent Phosphorylated Basic Helix-Loop-Helix Transcription Factors in Guard Cells of Vicia faba by Mass Spectrometry
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Takahashi, Yohei
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[6] Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity conditions
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[7] Jasmonic Acid-Dependent MYC Transcription Factors Bind to a Tandem G-Box Motif in the YUCCA8 and YUCCA9 Promoters to Regulate Biotic Stress Responses
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[8] Interaction of Arabidopsis TGA3 and WRKY53 transcription factors on Cestrum yellow leaf curling virus (CmYLCV) promoter mediates salicylic acid-dependent gene expression in planta
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[9] Interaction of Arabidopsis TGA3 and WRKY53 transcription factors on Cestrum yellow leaf curling virus (CmYLCV) promoter mediates salicylic acid-dependent gene expression in planta
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Das, Abhimanyu
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