Regulation of Retrotransposons in Drosophila melanogaster Somatic Tissues

被引：0

作者：

Milyaeva, P. A. ^{[1
,2
]}

Kukushkina, I. V. ^{[1
]}

Lavrenov, A. R. ^{[1
,3
]}

Kuzmin, I. V. ^{[1
]}

Kim, A. I. ^{[1
,2
]}

Nefedova, L. N. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Biol, Moscow 119234, Russia

[2] Shenzhen MSU BIT Univ, Fac Biol, Shenzhen 518172, Peoples R China

[3] Russian Acad Sci, Severtsov Inst Ecol & Evolut, Moscow 119071, Russia

来源：

MOLECULAR BIOLOGY | 2024年 / 58卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

retrotransposons; nanopore sequencing; Drosophila melanogaster; flamenco phenotype; PIWI PROTEINS; TRANSCRIPTION; TRANSPOSITION; EXPRESSION; PIRNAS; RNA;

D O I：

10.1134/S0026893324010096

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of retrotransposon activity in somatic tissues is a complex mechanism that has still not been studied in detail. It is strongly believed that siRNA interference is main mechanism of retrotransposon activity regulation outside the gonads, but recently was demonstrated that piRNA interference participates in retrotransposon repression during somatic tissue development. In this work, using RT-PCR, we demonstrated that during ontogenesis piRNA interference determinates retrotransposon expression level on imago stage and retrotransposons demonstrate tissue-specific expression. The major factor of retrotransposon tissue-specific expression is presence of transcription factor binding sites in their regulatory regions.

引用

页码：81 / 101

页数：21

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