An MMP-2 sensitive and reduction-responsive prodrug amphiphile for actively targeted therapy of cancer by hierarchical cleavage

被引：6
|
作者：
Zhang, Xueni [1 ,2 ]
Dai, Lihui [1 ,2 ]
Ding, Yumeng [1 ,2 ]
Liu, Qian [1 ,2 ]
Li, Xiaoya [1 ,2 ]
Liu, Mengting [1 ,2 ]
Meng, Meng [1 ,2 ]
Pan, Jie [3 ]
Xi, Rimo [1 ,2 ]
Yin, Yongmei [1 ,2 ]
机构：
[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China
[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China
[3] Tiangong Univ, Sch Chem Engn & Technol, Tianjin 300387, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 07期
基金：
对外科技合作项目（国际科技项目）;
关键词：
Diseases; -; Micelles;
D O I：
10.1039/d2cc05586d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A hierarchically cleaved amphiphile, mPEG-pep-etcSS-CPT, was synthesized to pursue actively targeted cancer therapy through self-assembly. This micelle can respond to MMP-2 achieving dePEGylation and releasing RGD peptides to be internalized into targetable tumor cells. Inside the cell, free CPT could be released by reduction-response leading to cytotoxicity.
引用
收藏
页码：900 / 903
页数：4
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