Association Between Different Metabolic Markers and Metabolic Syndrome in an Outpatient Hyperuricemia Population: A Cross-Sectional Study

被引:0
|
作者
Li, Xin [1 ]
Huang, Bo [1 ]
Liu, Yue [1 ]
Wang, Meng [1 ]
Wang, Yi-Xuan [1 ]
Feng, Kai-Lei [1 ]
Cui, Jing-Qiu [1 ]
机构
[1] Tianjin Med Univ Gen Hosp, Dept Endocrinol & Metab, An Shan Dao 154, Tianjin 300052, Peoples R China
基金
中国国家自然科学基金;
关键词
metabolic syndrome; serum uric acid-to-creatinine ratio; serum uric acid to high-density lipoprotein cholesterol; triglyceride to high-density lipoprotein cholesterol; TyG index; SERUM URIC-ACID; LIPOPROTEIN CHOLESTEROL RATIO; TRIGLYCERIDE-GLUCOSE INDEX; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; RISK;
D O I
10.2147/DMSO.S443472
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Hyperuricemia (HUA) is often associated with metabolic syndrome (MetS). However, the role of different metabolic markers in the screening of MetS in out-patients with hyperuricemia is unclear. The study aims to investigate the relationship between different metabolic indexes and MetS.Methods: A total of 399 hyperuricemia patients from Tianjin Medical University General Hospital from 2022 to 2023 were included in this study. We collected demographic, anthropometric, and biochemical data on each subject. And calculate serum uric acid-tocreatinine ratio (SUA/Cr), serum uric acid to high-density lipoprotein cholesterol (UHR), triglyceride to high-density lipoprotein cholesterol (THR), and triglyceride and glucose (TyG) index. Binary logistic regression modeling was performed to explore the association between different metabolic markers and MetS.Results: Out of the 399 subjects, 28.3% had MetS. UHR, THR, and TyG index were significantly higher in the MetS group than those in the control group (p<0.05), which were associated with an increased risk of MetS. However, SUA/Cr was not associated with MetS (p>0.05). TyG index had a stronger relationship with the risk of MetS (OR 5.476, 95% CI 2.210-13.569, p<0.001). The cut-off with the biggest Youden index of the TyG index was 9.13 and the area under the curve (AUC) was 0.719.Conclusion: A high TyG index is associated with an increased risk of MetS in HUA patients. These findings might help screen MetS in individuals with HUA and could be more standardized management of patients with high uric acid in outpatient clinics.
引用
收藏
页码:3967 / 3978
页数:12
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