Cis-(3-benzyloxy-1,1-cyclobutanedicarboxylato κ2O,O′)bis(1-methyl-1H-pyrazole)platinum(II)

被引：0
|
作者：
Pavlova, Anna S. [1 ]
Buslaev, Daniil A. [1 ]
Borisova, Nataliya E. [1 ,2 ]
Temnov, Victor V. [1 ]
Nazarov, Alexey A. [1 ]
Podrugina, Tatyana A. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Leninskie Gory 1-3, Moscow 119991, Russia
[2] RAS, Lab Arctic Mineral & Mat Sci, Kola Sci Ctr, 14 Fersman St, Apatity 184209, Russia
来源：
MOLBANK | 2023年 / 2023卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
platinum (II) complexes; 1-methyl-1H-pyrazole ligand; 3-(benzyloxy)cyclobutane-1; 1-dicarboxylic acid; antiproliferative activity; DICHLOROACETATE INDUCES APOPTOSIS; PLATINUM(II) COMPLEXES; ANTICANCER ACTIVITY; DERIVATIVES; CISPLATIN; AGENTS;
D O I：
10.3390/M1564
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A huge variety of types of cancer makes it necessary to search for new effective drugs with a defined molecular target. Modification of substituents in ligands based on 3-hydroxy-1,1-cyclobutanedicarboxylic acid are one of the effective directions to design a better version of carboplatin. In the present study, we combined in one molecule a derivative of 3-hydroxycyclobutane-1,1-dicarboxylic acid and N-methylpyrazole as a carrier ligand. The antiproliferative of the novel complex Pt(II) was established for cell lines HCT116, MCF7, A549, and WI38 by means of a standard MTT colorimetric assay.
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页数：5
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