In vitro cytotoxic capacity against tumor cell lines and antioxidant activity of acidic polysaccharides isolated from the Andean Patagonian fungus Phylloporia boldo

被引：6

作者：

Albornoz, Veronica ^{[1
,3
]}

Casas-Arrojo, Virginia ^{[2
]}

Figueroa, Fabian ^{[3
]}

Riquelme, Cristian ^{[4
,5
]}

Hernandez, Victor ^{[3
]}

Rajchenberg, Mario ^{[6
,7
]}

Smith, Carlos T. ^{[1
]}

Campos, Victor L. ^{[1
]}

Abdala-Diaz, Roberto T. ^{[2
]}

Becerra, Jose ^{[3
,8
]}

Perez, Claudia ^{[3
,8
]}

Cabrera-Pardo, Jaime R. ^{[9
]}

机构：

[1] Univ Concepcion, Fac Biol Sci, Dept Microbiol, Concepcion, Chile

[2] Univ Malaga, Fac Sci, Dept Ecol, Malaga, Spain

[3] Univ Concepcion, Fac Nat & Oceano Graph Sci, Dept Bot, Concepcion, Chile

[4] Univ Austral Chile, Fac Ciencias, Escuela Graduados, Programa Doctorado Ciencias Menc Ecol & Evoluc, Valdivia, Chile

[5] Univ Austral Chile, Inst Bioquim & Microbiol, Lab Micol, Valdivia, Chile

[6] CIEFAP Ctr Invest & Extens Forestal Andino Patago, Esquel, Chubut, Argentina

[7] Consejo Nacl Invest Cient & Tecn CONICET, Esquel, Argentina

[8] Univ Concepcion, Unidad Desarrollo Tecnol, Coronel, Chile

[9] Univ Bio Bio, Fac Ciencias, Dept Quim, Lab Quim Aplicada & Sustentable LabQAS, Concepcion, Chile

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 24期

关键词：

Phylloporia; acidic polysaccharides; cytotoxic activity; antioxidant activity; STRUCTURAL-CHARACTERIZATION; CORDYCEPS-SINENSIS; PHELLINUS; HYMENOCHAETALES; ANTITUMOR;

D O I：

10.1080/14786419.2022.2158331

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Fungal polysaccharides possess a broad biological activity, including cytotoxic and antioxidant activities. This work aimed to evaluate the cytotoxic and antioxidant activity of the acidic polysaccharides of Phylloporia boldo strain (named PBAP40). Cytotoxic activity of polysaccharide was evaluated determining the viability of three tumor cell lines by MTT assay. The effect of acidic polysaccharide on the cell cycle of HL-60 cell line was evaluated by flow cytometry, and the antioxidant activity was determined by DPPH and ABTS assays. PBAP40 showed cytotoxic effects in tumor cell lines. Results suggest that P. boldo acidic polysaccharides arrested tumor cells in the cell cycle Sub G1 phase. The acidic polysaccharides of PBAP40 strain were not cytotoxic for the non-tumor cell line. PBAP40 also showed excellent antioxidant activity. The FT-IR analysis of the acidic polysaccharides indicated the presence of glucans bearing alpha- and beta- type glycosidic bonds.

引用

页码：4274 / 4279

页数：6

共 38 条

[1] Antioxidant and Cytotoxic activity of Steroidal Alkaloids Isolated from Sarcococca saligna against DPPH and HeLa Cell Lines
Jan, Naeem Ullah
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Amin, Fazli
Rahim, Haroon
Abbas, Sudhair
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Aman, Salman
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[2] Statins potentiate cytostatic/cytotoxic activity of sorafenib but not sunitinib against tumor cell lines in vitro
Bil, Jacek
Zapala, Lukasz
Nowis, Dominika
Jakobisiak, Marek
Golab, Jakub
CANCER LETTERS, 2010, 288 (01) : 57 - 67
[3] CYTOTOXIC ACTIVITY OF PARIS QUADRIFOLIA EXTRACT AND ISOLATED SAPONIN FRACTIONS AGAINST HUMAN TUMOR CELL LINES
Stefanowicz-Hajduk, Justyna
Kawiak, Anna
Gajdus, Jerzy
Ochocka, J. Renata
Paszkiewicz, Monika
Stepnowski, Piotr
Lojkowska, Ewa
ACTA BIOLOGICA CRACOVIENSIA SERIES BOTANICA, 2011, 53 (02) : 127 - 131
[4] Alkaloids isolated from Tropaeolum tuberosum with cytotoxic activity and apoptotic capacity in tumour cell lines
Apaza Ticona, Luis
Arnanz Sebastian, Julia
Serban, Andreea Madalina
Rumbero Sanchez, Angel
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[5] Antioxidant capacity of hesperidin from Citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines
Al-Ashaal, Hanan A.
El-Sheltawy, Shakinaz T.
PHARMACEUTICAL BIOLOGY, 2011, 49 (03) : 276 - 282
[6] Cytotoxic activity of saponins from Camassia leichtlinii against human oral tumor cell lines
Furuya, S
Takayama, F
Mimaki, Y
Sashida, Y
Satoh, K
Sakagami, H
ANTICANCER RESEARCH, 2001, 21 (2A) : 959 - 964
[7] The cytotoxic potential of polyphenols extracted from eight lichen species and their antioxidant activity against the cancer cell lines
Furmanek, Lukasz
Zurek, Natalia
Kapusta, Ireneusz
Seaward, Mark R. D.
Czarnota, Pawel
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[8] In vitro Cytotoxic Activity of Extracts and Isolated Constituents of Salvia leriifolia BENTH. against a Panel of Human Cancer Cell Lines
Tundis, Rosa
Loizzo, Monica R.
Menichini, Federica
Bonesi, Marco
Colica, Carmela
Menichini, Francesco
CHEMISTRY & BIODIVERSITY, 2011, 8 (06) : 1152 - 1162
[9] Bioactive sesquiterpene lactones from Centaurea species and their cytotoxic/cytostatic activity against human cell lines in vitro
Koukoulitsa, E
Skaltsa, H
Karioti, A
Demetzos, C
Dimas, K
PLANTA MEDICA, 2002, 68 (07) : 649 - 652
[10] Cytotoxic activity against tumour cell lines and anti-inflammatory effects of compounds isolated from Xylopia aromatica
Estrada, O.
Gonzalez, l
Mijares, M.
Fernandez, A.
Ruiz, M.
Taylor, P.
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