Role of microbiota and microbiota-derived short-chain fatty acids in PDAC

被引：7
|
作者：
Temel, Hulya Yilmaz [1 ]
Kaymak, Oznur [1 ]
Kaplan, Seren [1 ]
Bahcivanci, Basak [2 ]
Gkoutos, Georgios V. [2 ,3 ,4 ]
Acharjee, Animesh [2 ,3 ,4 ]
机构：
[1] Ege Univ, Dept Bioengn, Fac Engn, Izmir, Turkey
[2] Univ Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England
[3] Queen Elizabeth Hosp Birmingham, Natl Inst Hlth Res Surg Reconstruct, Birmingham, W Midlands, England
[4] MRC Hlth Data Res UK HDR UK, Birmingham, W Midlands, England
来源：
CANCER MEDICINE | 2023年 / 12卷 / 05期
基金：
英国科研创新办公室; 欧盟地平线“2020”;
关键词：
host-microbe interactions; inflammation; microbiome; microbiota; pancreatic ductal adenocarcinoma; SCFA; PANCREATIC DUCTAL ADENOCARCINOMA; KAPPA-B ACTIVATION; SODIUM-BUTYRATE; GUT MICROBIOTA; TUMOR MICROBIOME; BACTERIAL TRANSLOCATION; INTESTINAL MICROBIOTA; COLONIC INFLAMMATION; METABOLITE BUTYRATE; HELICOBACTER-PYLORI;
D O I：
10.1002/cam4.5323
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in PDAC. Metabolic regulation in the gut is a complex process that involves microbiome and microbiome-derived short-chain fatty acids (SCFAs). SCFAs regulate inflammation, as well as lipid and glucose metabolism, through different pathways. This review aims to summarize recent developments in PDAC in the context of gut and oral microbiota and their associations with short-chain fatty acid (SCFA). In addition to this, we discuss possible therapeutic applications using microbiota in PDAC.
引用
下载
收藏
页码：5661 / 5675
页数：15
相关论文
共 50 条
  • [1] The emerging role of microbiota-derived short-chain fatty acids in immunometabolism
    Jasim, Saade Abdalkareem
    Opulencia, Maria Jade Catalan
    Ramirez-Coronel, Andres Alexis
    Abdelbasset, Walid Kamal
    Abed, Murtadha Hasan
    Markov, Alexander
    Al-Awsi, Ghaidaa Raheem Lateef
    Shamsiev, Jamshid Azamatovich
    Hammid, Ali Thaeer
    Shalaby, Mohammed Nader
    Karampoor, Sajad
    Mirzaei, Rasoul
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 110
  • [2] Role of microbiota-derived short-chain fatty acids in cancer development and prevention
    Mirzaei, Rasoul
    Afaghi, Azam
    Babakhani, Sajad
    Sohrabi, Masoud Reza
    Hosseini-Fard, Seyed Reza
    Babolhavaeji, Kiandokht
    Akbari, Shabnam Khani Ali
    Yousefimashouf, Rasoul
    Karampoor, Sajad
    BIOMEDICINE & PHARMACOTHERAPY, 2021, 139
  • [3] Dual role of microbiota-derived short-chain fatty acids on host and pathogen
    Mirzaei, Rasoul
    Dehkhodaie, Elahe
    Bouzari, Behnaz
    Rahimi, Mandana
    Gholestani, Abolfazl
    Hosseini-Fard, Seyed Reza
    Keyvani, Hossein
    Teimoori, Ali
    Karampoor, Sajad
    BIOMEDICINE & PHARMACOTHERAPY, 2022, 145
  • [4] Role of microbiota-derived short-chain fatty acids in nervous system disorders
    Mirzaei, Rasoul
    Bouzari, Behnaz
    Hosseini-Fard, Seyed Reza
    Mazaheri, Maryam
    Ahmadyousefi, Yaghoub
    Abdi, Milad
    Jalalifar, Saba
    Karimitabar, Zahra
    Teimoori, Ali
    Keyvani, Hossein
    Zamani, Farhad
    Yousefimashouf, Rasoul
    Karampoor, Sajad
    BIOMEDICINE & PHARMACOTHERAPY, 2021, 139
  • [5] Gut microbiota-derived short-chain fatty acids and kidney diseases
    Li, Lingzhi
    Ma, Liang
    Fu, Ping
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2017, 11 : 3531 - 3542
  • [6] Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment
    Yang, Fan
    Chen, Hengwen
    Gao, Yonghong
    An, Na
    Li, Xinye
    Pan, Xiandu
    Yang, Xinyu
    Tian, Li
    Sun, Jiahao
    Xiong, Xingjiang
    Xing, Yanwei
    BIOMEDICINE & PHARMACOTHERAPY, 2020, 130
  • [7] Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids
    Chang H. Kim
    Cellular & Molecular Immunology, 2021, 18 : 1161 - 1171
  • [8] Microbiota-derived short-chain fatty acids as modulators of intestinal serotonin transporter
    Latorre, E.
    Forcen, A.
    Buey, B.
    Grasa, L.
    Mesonero, J. E.
    FEBS OPEN BIO, 2021, 11 : 46 - 47
  • [9] Immunomodulatory roles of microbiota-derived short-chain fatty acids in bacterial infections
    Ranjbar, Reza
    Vahdati, Saeed Niazi
    Tavakoli, Sara
    Khodaie, Reza
    Behboudi, Hossein
    BIOMEDICINE & PHARMACOTHERAPY, 2021, 141
  • [10] Anticancer Effects of Gut Microbiota-Derived Short-Chain Fatty Acids in Cancers
    Son, Mi-Young
    Cho, Hyun-Soo
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2023, 33 (07) : 849 - 856
12345