Acinetobacter infections have high rates of mortality due to an increasing incidence of infections by multidrug-resistant (MDR) and extensively-drug-resistant (XDR) strains. Therefore, new therapeutic strategies for the treatment of Acinetobacter infections are urgently needed. Acinetobacter spp. are Gram-negative coccobacilli that are obligate aerobes and can utilize a wide variety of carbon sources. Acinetobacter baumannii is the main cause of Acinetobacter infections, and recent work has identified multiple strategies A. baumannii uses to acquire nutrients and replicate in the face of host nutrient restriction. Acinetobacter infections have high rates of mortality due to an increasing incidence of infections by multidrug-resistant (MDR) and extensively-drug-resistant (XDR) strains. Therefore, new therapeutic strategies for the treatment of Acinetobacter infections are urgently needed. Acinetobacter spp. are Gram-negative coccobacilli that are obligate aerobes and can utilize a wide variety of carbon sources. Acinetobacter baumannii is the main cause of Acinetobacter infections, and recent work has identified multiple strategies A. baumannii uses to acquire nutrients and replicate in the face of host nutrient restriction. Some host nutrient sources also serve antimicrobial and immunomodulatory functions. Hence, understanding Acinetobacter metabolism during infection may provide new insights into novel infection control measures. In this review, we focus on the role of metabolism during infection and in resistance to antibiotics and other antimicrobial agents and discuss the possibility that metabolism may be exploited to identify novel targets to treat Acinetobacter infections.
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Midwestern Univ Chicago, Coll Pharm, Dept Pharm Practice, Downers Grove, IL USAMidwestern Univ Chicago, Coll Pharm, Dept Pharm Practice, Downers Grove, IL USA
Esterly, John S.
Richardson, Chad L.
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Midwestern Univ Chicago, Coll Pharm, Dept Pharm Practice, Downers Grove, IL USAMidwestern Univ Chicago, Coll Pharm, Dept Pharm Practice, Downers Grove, IL USA
Richardson, Chad L.
Eltoukhy, Noha S.
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Midwestern Univ Chicago, Coll Pharm, Dept Pharm Practice, Downers Grove, IL USA
Rush Univ, Med Ctr, Chicago, IL 60612 USAMidwestern Univ Chicago, Coll Pharm, Dept Pharm Practice, Downers Grove, IL USA
Eltoukhy, Noha S.
Qi, Chao
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NW Mem Hosp, Clin Microbiol Lab, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USAMidwestern Univ Chicago, Coll Pharm, Dept Pharm Practice, Downers Grove, IL USA
Qi, Chao
Scheetz, Marc H.
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Midwestern Univ Chicago, Coll Pharm, Dept Pharm Practice, Downers Grove, IL USAMidwestern Univ Chicago, Coll Pharm, Dept Pharm Practice, Downers Grove, IL USA
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Univ Calif Los Angeles, Dept Sociol, Los Angeles, CA 90024 USA
Inst Soc & Genet, Los Angeles, CA USAAmer Univ Beirut, Expt Pathol Immunol & Microbiol, Beirut, Lebanon
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Maulana Azad Med Coll, Dept Microbiol, Pathol Block,Bahadur Shah Zafar Marg, New Delhi 110002, IndiaMaulana Azad Med Coll, Dept Microbiol, Pathol Block,Bahadur Shah Zafar Marg, New Delhi 110002, India
Perween, Naz
Sehgal, Sonal
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Maulana Azad Med Coll, Dept Microbiol, Pathol Block,Bahadur Shah Zafar Marg, New Delhi 110002, IndiaMaulana Azad Med Coll, Dept Microbiol, Pathol Block,Bahadur Shah Zafar Marg, New Delhi 110002, India
Sehgal, Sonal
Prakash, S. Krishna
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Maulana Azad Med Coll, Dept Microbiol, Pathol Block,Bahadur Shah Zafar Marg, New Delhi 110002, IndiaMaulana Azad Med Coll, Dept Microbiol, Pathol Block,Bahadur Shah Zafar Marg, New Delhi 110002, India