The Chick Embryo and Its Structures as a Model System for Experimental Ophthalmology

被引:0
|
作者
Kravchenko, S. V. [1 ]
Myasnikova, V. V. [1 ,2 ]
Sakhnov, S. N. [1 ,2 ]
机构
[1] Minist Hlth Russian Federat, S Fyodorov Eye Microsurg Fed State Inst, Krasnodar Branch, Krasnodar, Russia
[2] Kuban State Med Univ, Minist Hlth Russian Federat, Krasnodar, Russia
关键词
chick embryo; chorioallantoic membrane; organ-on-a-chip; spinal ganglia culture; experimental ophthalmology; LESS CULTURE-SYSTEM;
D O I
10.1007/s10517-023-05718-0
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The possibilities of using the chick embryo and its individual structures as a model system in experimental ophthalmology are considered. Cultures of the retina and spinal ganglia from chick embryos are used in the development of new methods for the treatment of glaucomatous optic neuropathy and ischemic optic neuropathy. The chorioallantoic membrane is used for modelling vascular pathologies of the eye, screening of anti-VEGF drugs, and assessing biocompatibility of implants. Co-culturing of chick embryo nervous tissue and human corneal cells makes it possible to study the processes of corneal reinnervation. The use of chick embryo cells and tissues in the "organ-on-a-chip" system opens up wide opportunities for fundamental and applied ophthalmological studies.
引用
收藏
页码:405 / 412
页数:8
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