Prognostic significance of head and neck spindle cell carcinoma

被引：9

作者：

Patel, Aman M. M. ^{[1
]}

Choudhry, Hannaan S. S. ^{[1
]}

Desai, Amar D. D. ^{[1
]}

Shah, Vraj P. P. ^{[1
]}

Patel, Prayag ^{[1
]}

Eloy, Jean Anderson ^{[1
,2
,3
,4
,5
]}

Roden, Dylan F. F. ^{[1
]}

Fang, Christina H. H. ^{[6
,7
]}

机构：

[1] Rutgers New Jersey Med Sch, Dept Otolaryngol Head & Neck Surg, Newark, NJ USA

[2] Rutgers New Jersey Med Sch, Neurol Inst New Jersey, Ctr Skull Base & Pituitary Surg, Newark, NJ USA

[3] Rutgers New Jersey Med Sch, Dept Neurol Surg, Newark, NJ USA

[4] Rutgers New Jersey Med Sch, Dept Ophthalmol & Visual Sci, Newark, NJ USA

[5] Robert Wood Johnson Barnabas Hlth, Dept Otolaryngol & Facial Plast Surg, St Barnabas Med Ctr, Livingston, NJ USA

[6] Montefiore Med Ctr, Albert Einstein Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Bronx, NY USA

[7] Univ Hosp, Montefiore Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Albert Einstein Sch Med, 3400 Bainbridge Ave,Med Arts Pavil Bldg,3rd Floor, Bronx, NY 10467 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 03期

关键词：

National Cancer Database; overall survival; primary site; spindle cell; squamous cell; PAPILLOMAVIRUS-RELATED HEAD; UPPER AERODIGESTIVE TRACT; SARCOMATOID CARCINOMA; SQUAMOUS CARCINOMA; CLINICOPATHOLOGICAL ASSESSMENT; MUCOUS-MEMBRANES; LARYNX; SURVIVAL; CANCER; PSEUDOSARCOMA;

D O I：

10.1002/hed.27285

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundOur study investigates the prognostic significance of spindle cell histology on overall survival (OS) of conventional head and neck squamous cell carcinoma (HNSCC). MethodsThe 2004 to 2017 National Cancer Database was queried for patients with head and neck spindle cell carcinoma (HNSpCC) (n = 1572) or HNSCC (n = 242 697) of the oral cavity, major salivary glands, sinonasal tract, oropharynx, hypopharynx, and larynx treated with curative intent. ResultsPatients with HNSpCC presented more frequently with higher-grade tumors and cN0 disease than those with HNSCC (p < 0.001). In the oral cavity, the HR for death for SpCC compared with SCC was 1.33 (p < 0.001). In the oropharynx, the HR for death for SpCC compared with SCC was 1.47 (p = 0.028). ConclusionsAfter adjusting for patient, tumor, and treatment characteristics, SpCC histology had an independent adverse prognostic effect on OS in the oral cavity and oropharynx. SpCC histology does not necessarily portend poorer survival in all HNSCC.

引用

页码：685 / 696

页数：12

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