Effects of electroconvulsive therapy on the use of anxiolytics and sleep medications: a propensity score-matched analysis

被引：3

作者：

Tsuboi, Takashi ^{[1
]}

Takaesu, Yoshikazu ^{[2
]}

Hasegawa, Naomi ^{[3
]}

Ochi, Shinichiro ^{[4
]}

Fukumoto, Kentaro ^{[5
]}

Ohi, Kazutaka ^{[6
]}

Muraoka, Hiroyuki ^{[7
]}

Okada, Tsuyoshi ^{[8
]}

Kodaka, Funitoshi ^{[9
]}

Igarashi, Shun ^{[1
,3
]}

Iida, Hitoshi ^{[10
]}

Kashiwagi, Hiroko ^{[11
]}

Hori, Hikaru ^{[10
]}

Ichihashi, Kayo ^{[12
]}

Ogasawara, Kazuyoshi ^{[13
]}

Hashimoto, Naoki ^{[14
]}

Iga, Jun-Ichi ^{[4
]}

Nakamura, Toshinori ^{[15
]}

Usami, Masahide ^{[16
]}

Nagasawa, Tatsuya ^{[17
]}

Kido, Mikio ^{[18
]}

Komatsu, Hiroshi ^{[19
]}

Yamagata, Hirotaka ^{[20
]}

Atake, Kiyokazu ^{[21
]}

Furihata, Ryuji ^{[22
]}

Kikuchi, Saya ^{[19
]}

Horai, Tadasu ^{[23
]}

Takeshima, Masahiro ^{[24
]}

Hirano, Yoji ^{[25
]}

Makinodan, Manabu ^{[26
]}

Matsumoto, Junya ^{[3
]}

Miura, Kenichiro ^{[3
]}

Hishimoto, Akitoyo ^{[27
]}

Numata, Shusuke ^{[28
]}

Yamada, Hisashi ^{[29
]}

Yasui-Furukori, Norio ^{[30
]}

Inada, Ken ^{[7
]}

Watanabe, Koichiro ^{[1
]}

Hashimoto, Ryota ^{[3
]}

机构：

[1] Kyorin Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan

[2] Univ Ryukyus, Grad Sch Med, Dept Neuropsychiat, Nishihara, Okinawa, Japan

[3] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Pathol Mental Dis, Tokyo, Japan

[4] Ehime Univ, Dept Neuropsychiat Mol & Funct, Grad Sch Med, Toon, Japan

[5] Iwate Med Univ, Dept Neuropsychiat, Morioka, Iwate, Japan

[6] Gifu Univ, Dept Psychiat, Grad Sch Med, Gifu, Japan

[7] Kitasato Univ, Dept Psychiat, Sch Med, Sagamihara, Kanagawa, Japan

[8] Jichi Med Univ, Dept Psychiat, Yakushiji, Japan

[9] Jikei Univ, Dept Psychiat, Sch Med, Minato Ku, Tokyo, Japan

[10] Fukuoka Univ, Fac Med, Dept Psychiat, Fukuoka, Japan

[11] Natl Ctr Hosp, Natl Ctr Neurol & Psychiat, Dept Forens Psychiat, Tokyo, Japan

[12] Univ Tokyo Hosp, Dept Neuropsychiat, Bunkyo Ku, Tokyo, Japan

[13] Nagoya Univ Hosp, Ctr Postgrad Clin Training & Career Dev, Nagoya, Aichi, Japan

[14] Hokkaido Univ, Dept Psychiat, Grad Sch Med, Sapporo, Hokkaido, Japan

[15] Shinshu Univ, Dept Psychiat, Sch Med, Matsumoto, Nagano, Japan

[16] Kohnodai Hosp, Natl Ctr Global Hlth & Med, Dept Child & Adolescent Psychiat, Ichikawa, Japan

[17] Kanazawa Med Univ, Dept NeuroPsychiat, Uchinada, Ishikawa, Japan

[18] Univ Toyama, Dept Neuropsychiat, Grad Sch Med & Pharmaceut Sci, Toyama, Japan

[19] Tohoku Univ Hosp, Dept Psychiat, Sendai, Miyagi, Japan

[20] Yamaguchi Univ, Dept Neurosci, Div Neuropsychiat, Sch Med, Ube, Yamaguchi, Japan

[21] Nippon Telegraph & Tel West Corp, Kyushu Hlth Adm Ctr, Fukuoka, Japan

[22] Kyoto Univ, Agcy Student Support & Disabil Resources, Kyoto, Japan

[23] Kobe Univ, Dept Psychiat, Grad Sch Med, Kobe, Hyogo, Japan

[24] Akita Univ, Dept Neuropsychiat, Grad Sch Med, Akita, Japan

[25] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka, Japan

[26] Nara Med Univ, Dept Psychiat, Kashihara, Nara, Japan

[27] Yokohama City Univ, Dept Psychiat, Grad Sch Med, Yokohama, Kanagawa, Japan

[28] Tokushima Univ, Grad Sch Biomed Sci, Dept Psychiat, Tokushima, Japan

[29] Hyogo Med Univ, Dept Neuropsychiat, Nishinomiya, Hyogo, Japan

[30] Dokkyo Med Univ, Dept Psychiat, Sch Med, Soka, Saitama, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2023年 / 77卷 / 01期

关键词：

anxiolytics; electroconvulsive therapy; major depressive disorder; schizophrenia; sleep medications; BENZODIAZEPINE USE; MOOD; GUIDELINES; DISORDERS; ANXIETY;

D O I：

10.1111/pcn.13489

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aim: We investigated the association of electroconvulsive therapy (ECT) with anxiolytic and sleep medication use in patients with major depressive disorder (MDD) and schizophrenia (SZ). Methods: This nationwide observational study analyzed data from 3483 MDD inpatients and 6663 SZ inpatients. Patients with MDD and SZ were classified into those who underwent ECT during hospitalization and those who did not. A propensity score-matching method was performed to adjust for pre-admission characteristics and clinical information, which were expected bias between the two groups. Rates of anxiolytic and sleep medication use at discharge were compared in the matched sample. Results: 500 MDD patients were assigned to both groups. In the matched MDD sample, the rate of anxiolytic and sleep medication use at discharge was significantly lower in the ECT group than in the non-ECT group (64.9% vs. 75.8%, P = 1.7 x 10(-4)). In the ECT group, the rate of anxiolytic and sleep medication use at discharge was significantly lower than that prior to admission (64.9% vs. 73.2%, P = 1.2 x 10(-14)). 390 SZ patients were allocated. In the matched SZ sample, the ECT group was not significantly different from the non-ECT group in the rate of anxiolytics and sleep medications use at discharge (61.3% vs. 68.2%, P = 4.3 x 10(-2)). In the ECT group, the rate of anxiolytics and sleep medications use at discharge was significantly lower than that before admission (61.3% vs. 70.5%, P = 4.4 x 10(-4)), although this was not the primary outcome. Conclusion: Reduction of anxiolytic and sleep medication use may be considered positively when ECT is indicated for treatment of MDD.

引用

页码：30 / 37

页数：8

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