Osthole Exerts Neuroprotection in a Mouse Model of Parkinson's Disease

被引：0
|
作者：
Wang, Shuguang [1 ]
Ding, Shilei [1 ]
Wang, Yuling [1 ]
He, Caiyu [1 ]
Yao, Ruiping [1 ]
Jin, Hong [2 ]
机构：
[1] Chuzhou City Vocat Coll, Dept Pharmacol, Chuzhou 239000, Anhui, Peoples R China
[2] Chuzhou City Vocat Coll, Dept Nursing, Chuzhou 239000, Anhui, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2023年 / 21卷 / 01期
关键词：
Neuroprotection; Osthole; Parkinson's disease; Signaling pathway; NEURONAL DIFFERENTIATION; MICE; PHOSPHORYLATION; APOPTOSIS; PATHWAY; MOTOR; ACIDS;
D O I：
10.37290/ctnr2641-452X.21:10-17
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Osthole is a bioactive coumarin derivative isolated from Cnidium monnieri (L.) cusson that has been shown to exhibit neuroprotective effects in several in vitro and in vivo studies. Herein, we have investigated the potential neuroprotective effect of osthole in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of Parkinson's disease. Results of our studies show that osthole attenuates behavioral deficits, reverses dopamine and its metabolites, dopaminergic neuron damage, and promotes activation of the PI3K/AKT pathway in MPTP-treated mice. In conclusion, the activation of the PI3K/Akt pathway may be responsible for the protective effects of osthole in the mouse model of Parkinson's disease.
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收藏
页码：10 / 17
页数：8
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