A promising RNA nanotechnology in clinical therapeutics: a future perspective narrative review

被引:7
|
作者
Tolba, Mahmoud M. [1 ]
Jabbar, Abdul [2 ]
Afzal, Sadia [3 ]
Mahmoud, Mohammed [4 ]
Zulfiqar, Farheen [5 ]
El-Soudany, Ingy [6 ]
Samir, Salma [7 ]
Wadan, Al-Hassan Soliman [8 ]
Ellakwa, Takwa E. [9 ]
Ellakwa, Doha El-Sayed [10 ,11 ]
机构
[1] Minist Hlth & Populat, Pharmaceut Div, Faiyum, Egypt
[2] Univ Vet & Anim Sci, Fac Vet Sci, Dept Vet Med, Lahore, Punjab, Pakistan
[3] Women Univ Multan, Fac Life Sci, Dept Bot, Multan, Pakistan
[4] Ain Shams Univ, Fac Pharm, Cairo, Egypt
[5] Univ Vet & Anim Sci, Dept Food Sci & Human Nutr, Lahore, Punjab, Pakistan
[6] Pharos Univ Alexandria, Fac Pharm, Microbiol & Immunol Dept, Alexandria, Egypt
[7] Benha Univ, Fac Agr, Genet & Genet Engn Dept, Banha, Egypt
[8] Sinai Univ, Fac Dent, Arish Branch, North Sinai, Egypt
[9] Egyptian Russian Univ, Fac Pharm, Phys Chem, Badr City, Egypt
[10] Al Azhar Univ, Fac Pharm Girls, Dept Biochem & Mol Biol, Cairo, Egypt
[11] Sinai Univ, Fac Pharm, Dept Biochem, Kantra Branch, Ismailia, Egypt
来源
FUTURE SCIENCE OA | 2023年 / 9卷 / 08期
关键词
endosomal escape; endosomes; nanoparticles; physicochemical properties; ribose nucleic acid; RNA nanotechnology; GOLD NANOPARTICLES; GENE DELIVERY; DRUG-DELIVERY; PEPTIDES; ELASTIN; POLYMER;
D O I
10.2144/fsoa-2023-0067
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Nanotechnology is the use of materials that have unique nanoscale properties. In recent years, nanotechnologies have shown promising results for human health, especially in cancer treatment. The self-assembly characteristic of RNA is a powerful bottom-up approach to the design and creation of nanostructures through interdisciplinary biological, chemical and physical techniques. The use of RNA nanotechnology in therapeutics is about to be realized. This review discusses different kinds of nano-based drug delivery systems and their characteristic features. Plain language summaryA branch of nanotechnology called RNA nanotechnology involves designing, studying, and utilizing synthetic structures based on RNA. This review discusses different kinds of nano-based drug delivery systems and their characteristic features. It aims to provide an overview of nanoparticles as a delivery system for gene therapy to treat diseases such as cancer. In order to enhance nanoparticle efficacy, these systems should be designed with this in mind in order to develop and test delivery systems rationally and scientifically.
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页数:11
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