Association Between Insulin-Like Growth Factor-1 and Social Cognition in Huntington's Disease

被引：1

作者：

Gil-Polo, Cecilia ^{[1
]}

Martinez-Horta, Saul-Indra ^{[2
]}

Santalo, Frederic Sampedro ^{[2
]}

Martin-Palencia, Maria ^{[3
]}

Gundin-Menendez, Simon ^{[3
]}

Alvarez-Banos, Pilar ^{[4
]}

Maza-Pereg, Laura ^{[4
]}

Calvo, Sara ^{[5
]}

Collazo, Carla ^{[5
]}

Alonso-Garcia, Esther ^{[6
]}

Rinones-Mena, Esther ^{[6
]}

Arrabal-Alonso, Angela ^{[3
]}

Rodriguez, Juan Nunez ^{[3
]}

Saiz-Rodriguez, Miriam ^{[5
]}

Aguado, Laura ^{[1
]}

Mariscal, Natividad ^{[1
]}

Munoz-Siscart, Ignacio ^{[7
]}

Pineiro, Dolores ^{[7
]}

Rivadeneyra, Jessica ^{[5
]}

Diez-Fairen, Monica ^{[8
]}

Miguel-Perez, Irene ^{[1
]}

Cubo, Esther ^{[1
,9
]}

机构：

[1] Hosp Univ Burgos, Neurol Dept, Burgos 09006, Spain

[2] Hosp Santa Creu & Sant Pau, Neurol Dept, Movement Disorders Unit, Barcelona, Spain

[3] Hosp Univ Burgos, Biochem Anal Dept, Burgos, Spain

[4] Hosp Univ Burgos, Endocrinol Dept, Burgos, Spain

[5] Hosp Univ Burgos, Res Unit, Burgos, Spain

[6] Hosp Univ Burgos, Radiol Dept, Burgos, Spain

[7] Hosp Univ Burgos, Psychiat Dept, Burgos, Spain

[8] Hosp Mutua Terrassa, Genet Dept, Burgos, Spain

[9] Univ Burgos, Burgos, Spain

来源：

MOVEMENT DISORDERS CLINICAL PRACTICE | 2023年 / 10卷 / 02期

关键词：

Huntington's disease; chorea; hypothalamus; IGF-1; neuroimaging; social cognition; PHOSPHORYLATION;

D O I：

10.1002/mdc3.13613

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundInsulin-like growth factor 1 (IGF-1) seems to be involved in the neural circuits associated with social cognition and brain structure. ObjectivesTo investigate the association of IGF-1 levels with social cognition and brain structure in Huntington's disease (HD). MethodsWe evaluated social cognition using the Ekman test in 22 HD patients and 19 matched controls. Brain structure was assessed using standard volume-based voxel-based morphometry and surface-based cortical thickness pipeline. We analyzed the association of IGF-1 levels with social cognition and brain structure using adjusted regression analysis. ResultsSocial cognition was worse in HD patients (P < 0.001), on antidopaminergic drugs (P = 0.02), and with lower IGF-1 levels (P = 0.04). In neuroimaging analyses, lower IGF-1 levels were associated with social cognition impairment and atrophy mainly in frontotemporal regions (P < 0.05 corrected). ConclusionsIn HD, abnormal IGF-1 function seems to be associated with brain atrophy leading to clinical deficits in social cognition.

引用

页码：279 / 284

页数：6

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