Nucleic Acid Aptamer for Recognizing Vascular Endothelial Growth Factor (VEGF) Receptors

被引：0
|
作者：
Yoshitomi, Toru [1 ]
Yoshimoto, Keitaro [2 ]
机构：
[1] Natl Inst Mat Sci, Res Ctr Macromol & Biomat, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan
[2] Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci, 3-8-1 Komaba,Meguro Ku, Tokyo 1538902, Japan
来源：
BUNSEKI KAGAKU | 2024年 / 73卷 / 03期
关键词：
nucleic acid; aptamer; VEGR receptors; VEGF-A; signaling aptamer; G-QUADRUPLEXES; DNA APTAMER; MOLECULES; SELECTION; SERVER; BIND;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Vascular endothelial growth factor (VEGF) is a secreted protein that promotes angiogenesis, and VEGF-A is an important molecule that binds to vascular endothelial growth factor receptor (VEGFR)-1 and VEGFR-2 and activates VEGF signaling pathway. We have successfully identified a set of nucleic acid aptamers that bind specifically to VEGFR-1 and VEGFR-2 using a method with systematic evolution of ligands by exponential enrichment (SELEX) and nextgeneration sequencer that can identify even low -frequency sequences. In this comprehensive paper, we summarize the structural analyses of the obtained nucleic acid aptamers and their functions as (1) angiogenesis promoters and (2) signaling aptamers.
引用
收藏
页码：71 / 78
页数：8
相关论文
共 50 条
  • [1] Vascular endothelial growth factor (VEGF) and its receptors
    Neufeld, G
    Cohen, T
    Gengrinovitch, S
    Poltorak, Z
    [J]. FASEB JOURNAL, 1999, 13 (01): : 9 - 22
  • [2] The splice variants of vascular endothelial growth factor (VEGF) and their receptors
    Robinson, CJ
    Stringer, SE
    [J]. JOURNAL OF CELL SCIENCE, 2001, 114 (05) : 853 - 865
  • [3] Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in human neuroblastomas
    Langer, I
    Vertongen, P
    Perret, J
    Fontaine, J
    Atassi, G
    Robberecht, P
    [J]. MEDICAL AND PEDIATRIC ONCOLOGY, 2000, 34 (06): : 386 - 393
  • [4] Complexity in the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-receptors signaling
    Debabrata Mukhopadhyay
    Huiyan Zeng
    Resham Bhattacharya
    [J]. Molecular and Cellular Biochemistry, 2004, 264 : 51 - 61
  • [5] Complexity in the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-receptors signaling
    Mukhopadhyay, D
    Zeng, HY
    Bhattacharya, R
    [J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2004, 264 (1-2) : 51 - 61
  • [6] Investigating the differential activation of vascular endothelial growth factor (VEGF) receptors
    Cautiero Horta, Bruno Araujo
    Renno Sodero, Ana Carolina
    de Alencastro, Ricardo Bicca
    [J]. JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2009, 28 (03): : 287 - 296
  • [7] Vascular Endothelial Growth Factor (VEGF) Receptors: Drugs and New Inhibitors
    Musumeci, Francesca
    Radi, Marco
    Brullo, Chiara
    Schenone, Silvia
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (24) : 10797 - 10822
  • [8] Vascular endothelial growth factor (VEGF) receptors in choroidal neovascular membranes
    Amin, RH
    Frank, RN
    Eliott, D
    Puklin, JE
    Abrams, GW
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1997, 38 (04) : 3235 - 3235
  • [9] Vascular Endothelial Growth Factor (VEGF), VEGF Receptors and Their Inhibitors for Antiangiogenic Tumor Therapy
    Takahashi, Satoru
    [J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2011, 34 (12) : 1785 - 1788
  • [10] Expression of vascular endothelial growth factor (VEGF) and activated vascular endothelial growth factor receptors (VEGFR) in renal cell carcinoma
    Ha, Byeong Keun
    Park, Moonja Chung
    [J]. MODERN PATHOLOGY, 2006, 19 : 82 - 82
12345