Vitamin D and Osteogenesis Imperfecta in Pediatrics

被引：2

作者：

Coccia, Francesco ^{[1
]}

Pietrobelli, Angelo ^{[1
,2
,3
]}

Zoller, Thomas ^{[1
]}

Guzzo, Alessandra ^{[4
]}

Cavarzere, Paolo ^{[2
]}

Fassio, Angelo ^{[5
]}

Flodmark, Carl-Erik ^{[6
]}

Gatti, Davide ^{[5
]}

Antoniazzi, Franco ^{[1
,2
,7
]}

机构：

[1] Univ Verona, Sch Med, Dept Surg Sci Dent Gynecol & Pediat, Pediat Clin, I-37129 Verona, Italy

[2] Azienda Osped Univ Integrata, Pediat Clin C, I-37126 Verona, Italy

[3] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

[4] Univ Verona, Sch Med, Dept Pathol & Diagnost, I-37129 Verona, Italy

[5] Univ Verona, Sch Med, Dept Med, I-37129 Verona, Italy

[6] Lund Univ, Fac Med, Dept Clin Sci, S-22100 Lund, Sweden

[7] Ctr Diag & Treatment Rare Skeletal Dis Dev Age Ven, I-37126 Verona, Italy

来源：

PHARMACEUTICALS | 2023年 / 16卷 / 05期

关键词：

osteogenesis imperfecta; vitamin D; pediatrics; D DEFICIENCY; CHILDREN; ADOLESCENTS;

D O I：

10.3390/ph16050690

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Osteogenesis Imperfecta (OI) is a heterogeneous group of inherited skeletal dysplasias characterized by bone fragility. The study of bone metabolism, in these disease, is problematic in terms of clinical and genetic variability. The aims of our study were to evaluate the importance of Vitamin D levels in OI bone metabolism, reviewing studies performed on this topic and providing advice reflecting our experience using vitamin D supplementation. A comprehensive review on all English-language articles was conducted in order to analyze the influence of vitamin D in OI bone metabolism in pediatric patients. Reviewing the studies, contradictory data were found on the relationship between 25OH vitamin D levels and bone parameters in OI, and in several studies the baseline levels of 25OH D were below the threshold value of 75 nmol/L. In conclusion, according to the literature and to our experience, we highlight the importance of adequate vitamin D supplementation in children with OI.

引用

页数：8

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