Autophagy-dependent ferroptosis in kidney disease

被引：9
|
作者：
Yang, Yuanting [1 ]
Cheng, Jiayi [2 ]
Lin, Qisheng [1 ]
Ni, Zhaohui [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, RenJi Hosp, Shanghai Peritoneal Dialysis Res Ctr,Uremia Diag &, Shanghai, Peoples R China
[2] Tianping Community Hlth Serv Ctr, Shanghai, Peoples R China
来源：
FRONTIERS IN MEDICINE | 2023年 / 9卷
基金：
中国博士后科学基金;
关键词：
ferroptosis; autophagy; kidney disease; cell death; acute kidney injury; CELL-DEATH; FERRITINOPHAGY; METABOLISM; MANAGEMENT; NCOA4;
D O I：
10.3389/fmed.2022.1071864
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ferroptosis is a new type of cell death caused by the lack of glutathione peroxidase 4 (GPX4) and the imbalance of cellular redox. It is characterized by the accumulation of lipid peroxides on cell membranes. Multiple regulatory pathways of ferroptosis include the GPX4, glutamate-cystine antiporter (System Xc(-)), lipid metabolism, and iron metabolism pathways. Recent studies have reported that autophagy-dependent ferroptosis (ferroptosis meditated by ferritinophagy, lipophagy, and clockophagy) plays a significant role in the occurrence of several diseases, including diseases affecting the nerves, liver, lungs, and kidneys. This review provides an overview of research progress made on autophagy-dependent ferroptosis in kidney diseases.
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页数：7
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