Respective Involvement of the Right Cerebellar Crus I and II in Syntactic and Semantic Processing for Comprehension of Language

被引:11
|
作者
Nakatani, Hironori [1 ,2 ]
Nakamura, Yuko [3 ,4 ]
Okanoya, Kazuo [2 ,3 ,4 ,5 ,6 ]
机构
[1] Tokai Univ, Sch Informat & Telecommun Engn, Minato Ku, Tokyo 1088619, Japan
[2] RIKEN, Ctr Brain Sci, 2-1 Hirosawa, Wako, Saitama 3510198, Japan
[3] Univ Tokyo, Grad Sch Art & Sci, Ctr Evolutionary Cognit Sci, Meguro Ku, Tokyo 1538902, Japan
[4] Univ Tokyo, Inst Divers & Adaptat Human Mind UTIDAHM, Meguro Ku, Tokyo 1538902, Japan
[5] Univ Tokyo, Grad Sch Arts & Sci, Meguro Ku, 3-8-1 Komaba, Tokyo 1538902, Japan
[6] Teikyo Univ, Adv Comprehens Res Org, Itabashi Ku, 2-21-1 Kaga, Tokyo 1730003, Japan
来源
CEREBELLUM | 2023年 / 22卷 / 04期
关键词
Cerebellum; Internal model; Language; Functional connectivity; Functional magnetic resonance imagings; VERBAL WORKING-MEMORY; INTERNAL-MODELS; BRAIN; ORGANIZATION; CONNECTIVITY; LOCALIZATION; OPINION; ANATOMY; CORTEX; TIME;
D O I
10.1007/s12311-022-01451-y
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The right posterolateral portions of the cerebellum (crus-I/II) are involved in language processing. However, their functional role in language remains unknown. The cerebellum is hypothesized to acquire an internal model that is a functional copy of mental representations in the cerebrum and to contribute to cognitive function. In this research, based on the cerebellar internal model hypothesis, we conducted task-based and resting-state functional magnetic resonance imaging (fMRI) experiments to investigate the role of the cerebellum in the syntactic and semantic aspects of comprehension of sentences. In a syntactic task, participants read sentences with center-embedded hierarchical structures. The hierarchical level-dependent activity was found in the right crus-I as well as Broca's area (p < 0.05, voxel-based small volume correction (SVC)). In a semantic task, the participants read three types of sentences for investigation of sentence-level, phrase-level, and word-level semantic processing. The semantic level-dependent activity was found in the right crus-II as well as in the left anterior temporal lobe and the left angular gyrus (p < 0.05, voxel-based SVC). Moreover, the right crus-I/II showed significant activity when the cognitive load was high. Resting-state fMRI demonstrated intrinsic functional connectivity between the right crus-I/II and language-related regions in the left cerebrum (p < 0.05, voxel-based SVC). These findings suggest that the right crus-I and crus-II are involved, respectively, in the syntactic and semantic aspects of sentence processing. The cerebellum assists processing of language in the cerebrum when the cognitive load is high.
引用
收藏
页码:739 / 755
页数:17
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