Adult Organophosphate and Carbamate Insecticide Exposure and Sperm Concentration: A Systematic Review and Meta-Analysis of the Epidemiological Evidence

被引：6

作者：

Ellis, Lauren B. ^{[1
,2
,6
,7
]}

Molina, Karen ^{[2
]}

Robbins, C. Rebecca ^{[2
]}

Freisthler, Marlaina ^{[2
]}

Sgargi, Daria ^{[3
]}

Mandrioli, Daniele ^{[3
,4
]}

Perry, Melissa J. ^{[1
,5
]}

机构：

[1] Northeastern Univ, Bouve Coll Hlth Sci, Boston, MA 02115 USA

[2] George Washington Univ, Milken Inst Sch Publ Hlth, Dept Environm & Occupat Hlth, Washington, DC USA

[3] Ramazzini Inst, Cesare Maltoni Canc Res Ctr, Bologna, Italy

[4] Univ Bologna, Dept Agr & Food Sci, Bologna, Italy

[5] George Mason Univ, Coll Publ Hlth, 4400 Univ Dr, Fairfax, VA 22030 USA

[6] Northeastern Univ, Boston, MA 02115 USA

[7] George Washington Univ, Washington, DC 20052 USA

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2023年 / 131卷 / 11期

关键词：

OCCUPATIONAL PESTICIDE EXPOSURE; SEMEN QUALITY; POLYMORPHISM; METHODOLOGY; INFERTILITY;

D O I：

10.1289/EHP12678

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

BACKGROUND: Evidence ofthenegativeimpactsofcontemporaryuseinsecticidesonspermconcentrationhasincreasedoverthelastfewdecades; however, meta-analysesonthistopicarerare. OBJECTIVES: This investigationassessedthequalitativeandquantitativestrengthofepidemiologicalevidenceregardingadultexposuretotwoclasses of contemporaryuseinsecticides-organophosphates (OPs) and N-methyl carbamates(NMCs)-and spermconcentrationusingrobustandreproducible systematicreviewandmeta-analysismethods. METHODS: Three scientific databases(PubMed, Scopus, andWebofScience), twoU.S. governmentdatabases(NIOSHTIC-2andScience.gov), and five nongovernmentalorganizationwebsitesweresearchedforrelevantprimaryepidemiologicalstudiespublishedinanylanguagethrough11August 2022. RiskofbiasandstrengthofevidencewereevaluatedaccordingtoNavigationGuidesystematicreviewmethodology. Bias-adjustedstandardized meandifference effect sizeswerecalculatedandpooledusingathree-level, multivariaterandom-effect meta-analysismodelwithcluster-robust variance estimation. RESULTS: Across 20studies, 21studypopulations, 42effect sizes, and1,774adultmen, thepooledbias-adjustedstandardizedmeandifference in sperm concentrationbetweenadultmenmore- andless-exposedtoOPandNMCinsecticideswas -0:30 (95% CI: -0:49, -0:10; PSatt < 0:01). Sensitivity andsubgroupanalysesexploredstatisticalheterogeneityandvalidatedthemodelrobustness. Althoughthepooledeffect estimatewas modified byriskofbias, insecticideclass, exposuresetting, andrecruitmentsetting, itremainednegativeindirectionacrossallmeta-analyses. The body ofevidencewasratedtobeofmoderatequality, withsufficient evidenceofanassociationbetweenhigheradultOPandNMCinsecticideexposure andlowerspermconcentration. DISCUSSION: This comprehensiveinvestigationfoundsufficient evidenceofanassociationbetweenhigherOPandNMCinsecticideexposureand lower spermconcentrationinadults. Althoughadditionalcohortstudiescanbebeneficial to fill datagaps, thestrengthofevidencewarrantsreducing exposure toOPandNMCinsecticidesnowtopreventcontinuedmalereproductiveharm. https://doi.org/10.1289/EHP12678

引用

页数：21

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