Usefulness of controlled attenuation parameter in monitoring clinically relevant decline of hepatic steatosis for non-alcoholic fatty liver disease

被引:2
|
作者
Wang, Jing-Houng [1 ]
Ou, Hsin-You [2 ]
Yen, Yi-Hao [1 ]
Hung, Chao-Hung [1 ]
Lu, Sheng-Nan [1 ]
机构
[1] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Hepatogastroenterol, Kaohsiung, Taiwan
[2] Kaohsiung Chang Gung Mem Hosp, Dept Radiol, Kaohsiung, Taiwan
关键词
controlled attenuation parameter (CAP); magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF); non-alcoholic fatty liver disease (NAFLD); MANAGEMENT; DIAGNOSIS;
D O I
10.1111/liv.15626
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and AimsMagnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) is the reference standard of hepatic steatosis assessment. This study evaluates usefulness of controlled attenuation parameter (CAP) in monitoring the clinically relevant outcome by MRI-PDFF for non-alcoholic fatty liver disease (NAFLD) patients. MethodsNAFLD patients were enrolled prospectively. Instruction was given in lifestyle modifications with exercise and control of metabolic factors. MRI-PDFF and CAP were performed at enrollment and follow-up, with the diagnostic validity of CAP in monitoring clinically relevant outcome defined as a decline of >= 30% relative to baseline value by MRI-PDFF. ResultsA total of 75 patients (male/female: 49/26, mean age: 53.2) were enrolled. Baseline MRI-PDFF, CAP and liver stiffness was 14.4%, 300.2 dB/m and 6.5 kPa. In a median interval of 369 days, thirteen (17.3%) patients achieved clinically relevant outcome with decline of 46.7 dB/m by CAP, compared with increase of 5.1 in the other patients. In multivariate analysis, clinically relevant outcome was associated with changes (Delta) of CAP and glucose. Assessed by area under receiver operating curve, the performances of Delta CAP in predicting clinically relevant outcome were 0.815 and 0.808, and with the specificity of >90%, the Delta CAP cutoff was -46 dB/m and -15% relative to baseline value; sensitivity was 53.8% and 46.2% with negative predictive value of 90.3% and 88.9% respectively. ConclusionsFor NAFLD patients, CAP exhibited good performance in monitoring clinically relevant decline of hepatic steatosis in MRI-PDFF. With the cutoffs of -46 dB/m or -15%, Delta CAP is useful in excluding clinical relevant outcome achievement.
引用
收藏
页码:1901 / 1908
页数:8
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