Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study

被引：6

作者：

Chuang, Chun-Hsiang ^{[1
,2
]}

Li, Jhe-Yu ^{[1
,3
]}

King, Jung-Tai ^{[4
]}

Chen, Wei-Ta ^{[5
,6
,7
,8
]}

Chen, Shih-Pin ^{[5
,6
,7
]}

Wang, Yen-Feng ^{[5
,6
,7
]}

Liu, Hung-Yu ^{[5
,6
,7
]}

Hsiao, Fu-Jung ^{[7
]}

Pan, Li-Ling Hope ^{[7
]}

Wang, Shuu-Jiun ^{[5
,6
,7
]}

Lai, Kuan-Lin ^{[5
,6
,7
,9
]}

机构：

[1] Natl Tsing Hua Univ, Coll Educ, Res Ctr Educ & Mind Sci, Hsinchu, Taiwan

[2] Natl Tsing Hua Univ, Inst Informat Syst & Applicat, Coll Elect Engn & Comp Sci, Hsinchu, Taiwan

[3] Natl Taiwan Ocean Univ, Dept Comp Sci & Engn, Keelung, Taiwan

[4] Natl Dong Hwa Univ, Coll Hua, Shih Coll Educ, Hualien, Taiwan

[5] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurol, Taipei, Taiwan

[6] Natl Yang Ming Chiao Tung Univ, Coll Med, Taipei, Taiwan

[7] Natl Yang Ming Chiao Tung Univ, Brain Res Ctr, Taipei, Taiwan

[8] Keelung Hosp, Minist Hlth & Welf, Keelung, Taiwan

[9] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurol, 201,Sec 2,Shi Pai Rd, Taipei 11217, Taiwan

来源：

CEPHALALGIA | 2023年 / 43卷 / 10期

关键词：

Chronic migraine; heart rate variability; electrocardiogram; monthly headache days; flunarizine; VAGUS NERVE-STIMULATION; AUTONOMIC FUNCTION; MUSCLE-ACTIVITY; HEADACHE; IMPAIRMENT; HUMANS;

D O I：

10.1177/03331024231206781

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

AimThis study aimed to investigate the extent of autonomic nervous system dysfunction in patients with chronic migraine using heart rate variability analysis. In addition, we explored the potential association between heart rate variability and treatment outcomes in patients receiving preventive treatment.MethodsIn this cross-sectional and prospective study, we compared heart rate variability profiles in 81 preventive-naive chronic migraine patients and 58 healthy controls. In addition, treatment responses of patients, who received a 12-week treatment with flunarizine, were assessed in relation to baseline heart rate variability.ResultsWe observed that chronic migraine patients had a reduced heart rate variability, signifying autonomic dysfunction in comparison to healthy controls. Furthermore, patients presenting normal heart rate variability, characterized by a standard deviation exceeding 30 milliseconds in normal-to-normal RR intervals, experienced a superior response to flunarizine treatment. This improvement was exemplified by a significantly larger reduction in monthly headache days for patients with higher heart rate variability compared to those with lower heart rate variability: -9.7 (5.9) vs. -6.2 (6.0) days (p = .026).ConclusionsAutonomic dysfunction occurs in chronic migraine as evaluated by heart rate variability. A preserved function is associated with a better treatment outcome to flunarizine.Trial registration: Neurologic Signatures of Chronic Pain Disorders, NCT02747940. Registered 22 April 2016, https://clinicaltrials.gov/ct2/show/NCT02747940ConclusionsAutonomic dysfunction occurs in chronic migraine as evaluated by heart rate variability. A preserved function is associated with a better treatment outcome to flunarizine.Trial registration: Neurologic Signatures of Chronic Pain Disorders, NCT02747940. Registered 22 April 2016, https://clinicaltrials.gov/ct2/show/NCT02747940

引用

页数：15

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