Green synthesis and characterization of terbium orthoferrite nanoparticles decorated with g-C3N4 for antiproliferative activity against human cancer cell lines (Glioblastoma, and Neuroblastoma)

Accordingly, employing plant extracts for the green synthesis of different nanoparticles (NPs) has caught the interest of scientists, and researchers due to the ease of accessibility, widespread distribution, and safety of plants. In the current study, a TbFeO3/g-C3N4 nanocomposite was made using a green chemistry technique that utilized grape juice, which acts as an active capping, and reducing agent to create NPs with well-organized biological characteristics. Several methods, including HRTEM, TEM, SEM, XRD, BET-BJH, and VSM, were employed to characterize the produced NPs. The XRD results indicated that the produced NPs had particles with an average size of 38.74 +/- 2 nm, which the TEM examination verified. Additionally, the cytotoxicity of the NPs was examined to assess their anti-proliferative effects on the cancer cell lines T98, and SH-SY5. In the case of T98 cells, viability was about 60, 70 and 90% in concentration C1 to C4 respectively after 24 h of drug administration. And viability decreasing by pass the time. Also, viability reduce bout 65% in all concentration about SH-SY5Y cells, surprisingly only the first three concentrations, C1 to C3 caused cell death after 48 h of drug administration and in lower concentrations, the death rate should decrease with the passage of time, viability was about 80 and85% in C4 and C5 respectively. (c) 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).